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Dermatrol (Damp)

CLINICAL APPLICATIONS

* Any skin conditions that appear to be visibly wet and purulent, or contain pus, abscesses or oozing fluids.

* Skin conditions considered as wet, such as infectious eczema, lesions, ulcers, carbuncles, furuncles, cellulitis, rash, candidal infections, contact and stasis dermatitis, seborrheic dermatitis, herpes zoster, and acne vulgaris.

 

WESTERN THERAPEUTIC ACTIONS

* Antiallergic effect to relieve allergy

* Antipruritic function to relieve itching

* Anti-inflammatory activity to reduce skin swelling and inflammation

* Antibiotic effect to treat skin infection

* Antitoxin and antidote benefits to neutralize and antagonize chemicals, allergens and toxins

 

CHINESE THERAPEUTIC ACTIONS

* Clears heat, eliminates toxins

* Dispels wind, relieves itching

* Strengthens the Spleen, dispels dampness

 

DOSAGE

Take 3 to 4 capsules three times daily. Dosage can be increased up to 6 to 8 capsules three times daily in acute cases. This formula should not be taken for more than two months continuously.

 

INGREDIENTS


Bai Shao (Radix Paeoniae Alba)

Bo He (Herba Menthae)

Chai Hu (Radix Bupleuri)

Che Qian Zi (Semen Plantaginis)

Chi Shao (Radix Paeoniae Rubra)

Chuan Mu Tong (Caulis Clematidis Armandii)

Chuan Xiong (Rhizoma Chuanxiong)

Dang Gui (Radix Angelicae Sinensis)

Di Huang (Radix Rehmanniae)

Du Huo (Radix Angelicae Pubescentis)

Fang Feng (Radix Saposhnikoviae)

Fu Ling (Poria)

Gan Cao (Radix et Rhizoma Glycyrrhizae)

Geng Mi (Semen Oryzae)

Huang Bo (Cortex Phellodendri Chinensis)

Huang Lian (Rhizoma Coptidis)

Huang Qin (Radix Scutellariae)

Jie Geng (Radix Platycodonis)

Jing Jie (Herba Schizonepetae)

Lian Qiao (Fructus Forsythiae)

Long Dan (Radix et Rhizoma Gentianae)

Mu Dan Pi (Cortex Moutan)

Niu Bang Zi (Fructus Arctii)

Qian Hu (Radix Peucedani)

Qiang Huo (Rhizoma et Radix Notopterygii)

Shan Yao (Rhizoma Dioscoreae)

Shan Zhu Yu (Fructus Corni)

Sheng Jiang (Rhizoma Zingiberis Recens)

Shi Gao (Gypsum Fibrosum)

Shu Di Huang (Radix Rehmanniae Praeparata)

Tian Hua Fen (Radix Trichosanthis)

Yi Yi Ren (Semen Coicis)

Ze Xie (Rhizoma Alismatis)

Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle)

Zhi Mu (Rhizoma Anemarrhenae)

Zhi Qiao (Fructus Aurantii)

Zhi Zi (Fructus Gardeniae)


 

BACKGROUND

The skin is the largest organ in the body, and it functions as a protective barrier that keeps undesirable substances from entering. Because the skin is the physical barrier that separates the exterior from the interior, skin health can be affected by factors from both the outside and the inside. External factors that affect the skin include infection (bacteria, virus, and parasites), external exposure to allergens (poison ivy, poison oak, chemicals used in cosmetics or cleaning agents, and drugs used in skin creams), insect bites (spiders and ticks), or trauma. Internal factors that affect the skin include inhalation of allergens (dust, pollen, and dander), ingestion of allergens (peanuts, nuts, fish, wheat, eggs, and milk), intake of certain drugs (penicillin, sulfa drugs, aspirin, and opioids), autoimmune diseases (systemic lupus erythematosus, Sjögren’s syndrome, and psoriasis), and emotional or physical imbalance (stress and anxiety).

        Although there are multiple and complicated causes of skin disorders, the clinical manifestations are usually simple and straight-forward: most skin disorders have either wet or dry characteristics. Optimal treatment requires the use of medicinal substances to treat both the cause and the symptoms.

        Skin disorders with damp/wet characteristics may have open lesions with infection, inflammation, ulceration, pus, and abscesses; and they often affect areas with excessive moisture, such as toes, buttocks, armpits, groin, and under the breast. Examples of skin disorders with damp/wet characteristics include skin infection, skin ulcers, exudative skin lesions, sores, abscesses, carbuncles, furuncles, cellulitis, seborrheic dermatitis, and acne vulgaris.

        Skin disorders with dry characteristics often appear to be dry, red, flaky, and scaly with underlying damages to and atrophy of the skin. Examples of skin disorders with dry characteristics include psoriasis, atopic dermatitis, urticaria, rosacea, warts, tinea versicolor, erysipelas, and eczema.

 

FORMULA EXPLANATION

Acute dermatological disorders are generally due to wind-heat and toxic heat invasion, which is usually associated with physical contact or oral ingestion of allergen(s). On the other hand, chronic dermatological conditions involve more with the accumulation of dampness in the body, which is the result of improper diet or Spleen’s weakness in metabolism and transporting water. Dermatrol (Damp) has four groups of herbs to address both acute and chronic skin conditions with wet lesions.

        The first group of herbs drains dampness, strengthens the Spleen, and helps the body metabolize water. They include Che Qian Zi (Semen Plantaginis), Chuan Mu Tong (Caulis Clematidis Armandii), Fu Ling (Poria), Yi Yi Ren (Semen Coicis), Ze Xie (Rhizoma Alismatis) and Sheng Jiang (Rhizoma Zingiberis Recens). These herbs have diuretic and anti-inflammatory activities to reduce skin swelling and water retention.

        The second group of herbs expels wind and relieves itching: Bo He (Herba Menthae), Chai Hu (Radix Bupleuri), Qian Hu (Radix Peucedani), Chuan Xiong (Rhizoma Chuanxiong), Jie Geng (Radix Platycodonis), Du Huo (Radix Angelicae Pubescentis), Qiang Huo (Rhizoma et Radix Notopterygii), Fang Feng (Radix Saposhnikoviae), and Jing Jie (Herba Schizonepetae). These herbs have an antihistamine effect to treat allergy, and an antipruritic effect to relieve itching.

        The third group clears heat and eliminates toxins. Herbs in this group include Chi Shao (Radix Paeoniae Rubra), Huang Bo (Cortex Phellodendri Chinensis), Huang Lian (Rhizoma Coptidis), Huang Qin (Radix Scutellariae), Lian Qiao (Fructus Forsythiae), Long Dan (Radix et Rhizoma Gentianae), Mu Dan Pi (Cortex Moutan), Niu Bang Zi (Fructus Arctii), Shi Gao (Gypsum Fibrosum), Tian Hua Fen (Radix Trichosanthis), Zhi Mu (Rhizoma Anemarrhenae), and Zhi Zi (Fructus Gardeniae). These herbs have an antibiotic function to treat skin infection, and anti-inflammatory function to reduce skin swelling and inflammation.

        The fourth group of herbs aims to tonify blood and nourish yin, which is the underlying cause for chronic, non-healing rashes, sores, and dermatological problems. With abundant blood, wind cannot rise to cause further itching. This group of herbs tonifies yin and nourishes blood to prevent heat from flaring up and aggravating the symptoms. Herbs in this group include Bai Shao (Radix Paeoniae Alba), Dang Gui (Radix Angelicae Sinensis), Di Huang (Radix Rehmanniae), Geng Mi (Semen Oryzae), Shan Yao (Rhizoma Dioscoreae), Shan Zhu Yu (Fructus Corni), and Shu Di Huang (Radix Rehmanniae Praeparata). Chuan Xiong (Rhizoma Chuanxiong) and Zhi Qiao (Fructus Aurantii) promote qi and blood circulation and remove stagnation. Finally, Gan Cao (Radix et Rhizoma Glycyrrhizae) and Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) are used to harmonize the formula. As these herbs strengthen the underlying body constitution, they also regulate and balance the endocrine system, and in turn facilitate the release of endogenous corticosteroids as necessary to reduce swelling and inflammation.

        In summary, Dermatrol (Damp) effectively treats damp/wet skin disorders by using herbs to strengthen the Spleen and dry dampness, clear heat and eliminate toxins, and dispel wind and relieve itching.

 

CAUTIONS & CONTRAINDICATIONS

* This formula is contraindicated in patients with cold or deficiency cold signs.

* This formula is contraindicated during pregnancy and nursing.

* In addition to external factors (dry skin, atopic dermatitis, contact dermatitis, infections) and internal factors (allergic reactions through ingestion or inhalation), skin disorders may be caused by conditions such as cholestasis, chronic renal failure, hyper- or hypothyroidism, diabetes, iron deficiency, and polycythemia vera. Optimal treatment requires these conditions to be ruled out, or confirmed and treated.

* This formula is contraindicated for long-term use. Identification and elimination of the cause is the best long-term solution. When symptoms clear up, re-evaluate the condition and prescribe some other formulas to address the underlying cause of the skin condition. Many times the patient may have another attack and it is usually due to poor dietary habit, so it is essential to ask the patient to be extremely careful with what they eat in order to prevent future break outs.

* This herbal formula contains herbs that invigorate blood circulation, such as Dang Gui (Radix Angelicae Sinensis). Therefore, patients who are on anticoagulant or antiplatelet therapies, such as Coumadin (warfarin), should use this formula with caution, or not at all, as there may be a higher risk of bleeding and bruising.[1],[2],[3]

 

CLINICAL NOTES

* Yin Care, a topical herbal solution, may be applied topically to help relieve itching.

* This formula is designed by Dr. Jimmy Wei-Yen Chang and has worked effectively for over 90% of his patients who suffer from various dermatological conditions with damp/wet lesions. However, it is not to be used long term as the heat-clearing herbs may weaken the Spleen and Stomach. After the symptoms and signs improve or are alleviated, one must find the underlying cause and treat it so the lesions do not return. Taking the herbs at a large dosage or for a prolonged period of time may not be necessary as the triggering factors are either due to exposure to allergen or improper diet and lifestyle. Please refer to Nutrition and Lifestyle Instructions sections to help maintain a healthy constitution and clear skin.

 

Pulse Diagnosis by Dr. Jimmy Wei-Yen Chang:

* Wet skin lesions due to damp-heat accumulation: deep and forceful pulse on all three pulse positions (cun, guan, chi)

 

SUPPLEMENTARY FORMULAS

* For severe itching, add Silerex.

* For acne, add Dermatrol (Clear).

* To enhance the overall antibacterial function, add Herbal ABX.

* To enhance the overall antiviral function, add Herbal AVR.

* For severe inflammation, add Astringent Complex.

* With additional signs of fire manifesting in red eyes, red tongue, anger and/or constipation, add Gardenia Complex and Gentle Lax (Excess).

* With additional signs of damp accumulation due to Spleen and Stomach qi deficiencies, add Pinellia Complex.

* In chronic dermatological conditions where the surrounding skin of the lesion appears purple and the tongue is purple, add Circulation (SJ).

* For weakened immune system, wei (defensive) qi deficiency, or chronic overall deficient patients with inability to heal lesions and wounds, add a high dose of Immune +.

* For skin conditions due to exposure to chemicals, such as paint, nail polish, glue, drugs, pain killers, bleach, or aerosol, add Herbal DTX.

* For skin condition associated with stress, add Calm.

 

 

ACUPUNCTURE TREATMENT

Traditional Points:

* Quchi (LI 11), Xuehai (SP 10), Hegu (LI 4), Sanyinjiao (SP 6), Fengchi (GB 20), Dazhui (GV 14), Fengmen (BL 12), Fengshi (GB 31), Jianyu (LI 15), Zusanli (ST 36)

 

Classic Master Tung's Points:

* Eczema: Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Linggu (T 22.05), Minghuang (T 88.12), Tianhuang (T 88.13), Qihuang (T 88.14), Tianhuang (T 77.17), Dihuang (T 77.19), Renhuang (T 77.21), Jinqianshang (T 88.24), Jinqianxia (T 88.23) 

* Atopic dermatitis: Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Linggu (T 22.05), Zhisima (T 11.07)  

* Herpes zoster: Linggu (T 22.05), Tianhuang (T 88.13), Minghuang (T 88.12), Qihuang (T 88.14), Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Shuitong (T 1010.19), Shuijin (T 1010.20)

* Tinea versicolor: Tianhuang (T 88.13), Minghuang (T 88.12), Qihuang (T 88.14), Simashang (T 88.18), Simaxia (T 88.19), Simazhong (T 88.17), Shuijin (T 1010.20), Shuitong (T 1010.19). Bleed the LR area T5 – T9 and KI area T9 – T12 on the back with cupping. Bleed before needling for best result.

* Hives: Simashang (T 88.18), Simaxia (T 88.19), Simazhong (T 88.17), Tianhuang (T 77.17), Dihuang (T 77.19), Renhuang (T 77.21), Tianhuang (T 88.13), Minghuang (T 88.12), Qihuang (T 88.14), Zhisima (T 11.07)

* Dry, cracking hands/fingers: Mu (T 11.17), Zhisima (T 11.07)

 

Master Tung’s Points by Dr. Chuan-Min Wang:

* Wet, oozing lesions: Bleed Zhiwu (T 11.26). Needle Waisanguan (T 77.27).

 

Balance Method by Dr. Richard Tan:

* Right side: Sanjian (LI 3), Quchi (LI 11), Zhongzhu (TH 3), Tianjing (TH 10), Taibai (SP 3), Yinlingquan (SP 9)

* Left side: Chize (LU 5), Taiyuan (LU 9), Shaoshang (LU 11), Jingqu (LU 8), Zusanli (ST 36), Xiangu (ST 43), Jinggu (BL 64), Zhiyin (BL 67)

* Alternate sides from treatment to treatment.

 

Ear Acupuncture:

* Ah shi points, Endocrine, Subcortex, Lung, Shenmen, Sympathetic

 

Auricular Medicine by Dr. Li-Chun Huang:

* Rash and itching: Allergy Area, Shenmen, Sympathetic, Occiput, Nervous Subcortex, Lung, Diaphragm, Spleen, Liver. Bleed Ear Apex.

* Contact dermatitis: Allergic Area, Sympathetic, Adrenal Gland, Liver, Spleen, Lung, Endocrine, corresponding points (to the area affected). Bleed Ear Apex.

§ For dermatitis with severe pain, add Shenmen and Occiput.

* Eczema: Allergic Area, Lung, Sympathetic, Spleen, Shenmen, Endocrine, Occiput, Diaphragm, corresponding points (to the area affected). Bleed Ear Apex.

* Cutaneous pruritis: Shenmen, Occiput, Liver, Spleen, Lung, Endocrine, Diaphragm, Allergic Area. Bleed Ear Apex.

* Urticaria: Liver, Lung, Spleen, Diaphragm, Shenmen, Occiput, Allergic Area, Sympathetic, Endocrine, Adrenal Gland. Bleed Ear Apex.

* Severe itching: Prick five times on the ear apex, five times each on the helix near the Great Auricular Nerve and Lesser Occipital Nerve.

 

Taoist Ear Points by Jun-Qing Luo:

* Bleed the back of the ear for any visible veins. This is very effective for relieving itching and treatment of any dermatological disorders.

 

NUTRITION

* According to the five elements theory, the Spleen (earth element) generates the Lung (metal element). In order to be free of any skin condition, which is governed by the Lung (metal element), the Spleen (earth element) must be free from damaging foods. Consumption of these damaging foods, such as ones listed below, will worsen the patient’s condition and possibly make herbal treatment less effective or ineffective.

§ Seafood: especially shellfish, like crabs, oyster, scallops, clams, lobster, and shrimp (they enter the yangming Stomach channel).

§ Fermented foods: cheese or fermented tofu.

§ Dairy: milk, cream, yogurt, cheese, and ice cream.

§ Sugar: any and all foods containing sugar, such as cake and dessert.

§ Meat: lamb, beef, goose, and duck.

§ Deep-fried or greasy food.

§ Certain fruits: mango and durian.

§ Stimulants: coffee, alcohol, and energy drinks.

§ Carbohydrates: white rice or bread as they may damage the Spleen and in turn produce more dampness.

§ Spicy, pungent, aromatic vegetables: pepper, garlic, onions, basil, rosemary, cumin, fennel, anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili pepper, and wasabi.

* If the patient is allergic to any food or feels uncomfortable after eating certain foods, then it is best to avoid eating them.

 

The Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:

* Increase consumption of potatoes, broccoli, dandelion, mung beans, seaweed, pearl barley, azuki beans, corn silk, water chestnuts, winter melon, and watermelon.

* Mash fresh potato and apply locally, changing every four hours, for three days.

* Apply honey to affected area.

* Apply mashed daikon radish to affected area.

* Make tea from dandelion and corn silk.

* Boil soup from seaweed and winter melon, drinking at least one time per day for ten days.

* Externally, wash with equal portions of salt and borax, dissolved in warm water; wash area two to three times daily. Do not use internally.

 

LIFESTYLE INSTRUCTIONS

* To properly restore the immune function, the patient is advised to sleep by 10:00 p.m. so they may enter deep sleep by 1:00 a.m. (Liver time according to the Chinese Anatomical Clock) to fully rest the Liver to restore its detoxification functions.

* Avoid being overly tired from working or stress whenever possible.

* Do not scratch or irritate lesions as it might lead to scar formation and further infection.

* Proper skin care is important for treatment of skin conditions. Use cool or lukewarm water when bathing, mild or moisturizing soap, limited bathing duration and frequency, and avoid tight or irritating clothing.

 

PHARMACOLOGICAL AND CLINICAL RESEARCH

Skin disorders with damp/wet characteristics, such as skin infection, skin ulcers and exudative skin lesions, have open lesions with infection, inflammation, ulceration, pus, and abscesses. Causes of skin disorders with damp/wet characteristics may be external (infection, direct contact, trauma) or internal (ingestion or inhalation of allergens, autoimmune diseases, emotional or physical imbalance). Optimal treatment requires the use of medicinal substances to treat both the cause and the symptoms. Dermatrol (Damp) contains herbs with multiple pharmacological effects, including but not limited to antiallergic, antipruritic, anti-inflammatory, antibiotic, antitoxin, and antidotal.

        Dermatrol (Damp) contains many herbs with direct and general effects to treat skin disorders. Sheng Jiang (Rhizoma Zingiberis Recens) has a stimulant effect to promote and facilitate human normal epidermal keratinocytes and dermal fibroblasts cell growths.[4] Bo He (Herba Menthae) has been shown to increase local blood circulation to the skin to relieve itching and pain.[5] Jing Jie (Herba Schizonepetae) has a general effect on the skin, and has been used successfully to treat dermatological disorders, such as measles, pruritic rash, and itching.[6] Dang Gui (Radix Angelicae Sinensis) has an antipimple and an antieczema effect exerted through the regulation of nuclear factor kappa B, maleic dialdehyde (MDA), polymorphonuclear cells, interleukin-1β, inducible nitric oxide synthase, and tumor necrosis factor-α.[7] Lastly, Di Huang (Radix Rehmanniae) has been used with good success to treat rashes, urticaria, and contact dermatitis.[8]

        Dermatrol (Damp) utilizes many herbs with antiallergic and antipruritic effects to treat various skin disorders. Huang Qin (Radix Scutellariae) has a remarkable effect as an antiallergic agent. It inhibits histamine and leukotriene release from mast cells, with greater potency than Intal (cromolyn), a drug that prevents the release of inflammatory chemicals such as histamine from mast cells.[9] Furthermore, Huang Qin (Radix Scutellariae) also inhibits the passive cutaneous anaphylaxis reaction through its downregulation of the expression of various inflammatory mediators.[10] Jie Geng (Radix Platycodonis) also has a significant effect – it treats allergies by inhibiting the inflammatory cytokines and the Syk-dependent signaling cascades, according to in vivo and in vitro studies.[11] Shu Di Huang (Radix Rehmanniae Praeparata) has been shown to inhibit systemic allergic reactions in a dose-dependent manner through the inhibition of histamine release from the peritoneal mast cells and significant suppression of tumor necrosis factor-alpha (TNF-α) production.[12] Topical application of extract from Di Huang (Radix Rehmanniae) and Shu Di Huang (Radix Rehmanniae Praeparata) shows marked anti-inflammatory and antiallergic activities to treat atopic dermatitis by suppressing the expression of cytokines, chemokines, and adhesion molecules.[13] Niu Bang Zi (Fructus Arctii) has a significant antiallergic effect to reduce the release of inflammatory mediators through inhibition of degranulation and cys-leukotriene release.[14] It effectively treats allergic diseases, including atopic dermatitis, by inhibiting the expression of IL-4 and IL-5.[15] Furthermore, Zhi Mu (Rhizoma Anemarrhenae) has a strong antiallergic effect, and can be used to inhibit the passive cutaneous anaphylaxis reaction induced by the antigen-immunoglobulin E (IgE) complex.[16] Lastly, Jing Jie (Herba Schizonepetae) and Lian Qiao (Fructus Forsythiae) have an antipruritic effect to inhibit itch-scratch response induced by substance P.[17]

        Dermatrol (Damp) incorporates many herbs with anti-inflammatory effects to treat inflammatory skin disorders. Huang Qin (Radix Scutellariae), Huang Lian (Rhizoma Coptidis) and Huang Bo (Cortex Phellodendri Chinensis) all have anti-inflammatory activities, and may be used to treat different skin disorders.[18] Fu Ling (Poria) and Lian Qiao (Fructus Forsythiae) are two herbs with beneficial effects to treat skin diseases involving chronic inflammation. These two herbs have inhibitory effects on lipoxygenase, cyclo-oxygenase, and elastase activities, which are therapeutic targets in dermatological disorders.[19] Chai Hu (Radix Bupleuri) reduces inflammation by decreasing capillary permeability caused by histamine and 5-hydroxy-tryptamine.[20] Glycyrrhizin and glycyrrhetinic acid, two compounds from Gan Cao (Radix et Rhizoma Glycyrrhizae), have demonstrated marked anti-inflammatory effects by enhancing the overall duration of effect of cortisone. There are two proposed mechanisms of actions: they may enhance cortisone’s effect by decreasing liver metabolism, or they may increase plasma concentration by affecting protein binding.[21] The anti-inflammatory influence of glycyrrhizin and glycyrrhetinic acid is approximately 1/10th that of cortisone.[22] Lastly, other herbs with anti-inflammatory effects include Dang Gui (Radix Angelicae Sinensis),[23] Di Huang (Radix Rehmanniae),[24] Jing Jie (Herba Schizonepetae),[25] Fang Feng (Radix Saposhnikoviae),[26] Mu Dan Pi (Cortex Moutan),[27] Niu Bang Zi (Fructus Arctii),[28] Shan Yao (Rhizoma Dioscoreae),[29] Shan Zhu Yu (Fructus Corni),[30] Zhi Mu (Rhizoma Anemarrhenae),[31] and Zhi Zi (Fructus Gardeniae).[32]

        Dermatrol (Damp) utilizes many herbs with antibiotic effects to treat skin infections. Herbs with an antibacterial effect include Huang Bo (Cortex Phellodendri Chinensis),[33],[34]Huang Lian (Rhizoma Coptidis),[35] Huang Qin (Radix Scutellariae),[36],[37] Tian Hua Fen (Radix Trichosanthis),[38],[39] Jing Jie (Herba Schizonepetae),[40] Lian Qiao (Fructus Forsythiae),[41] Long Dan (Radix et Rhizoma Gentianae),[42] Mu Dan Pi (Cortex Moutan),[43] Zhi Zi (Fructus Gardeniae),[44] and Zhi Mu (Rhizoma Anemarrhenae).[45],[46] Herbs with an antiviral effect include Huang Lian (Rhizoma Coptidis),[47],[48],[49] Chai Hu (Radix Bupleuri),[50] Che Qian Zi (Semen Plantaginis),[51] Fang Feng (Radix Saposhnikoviae),[52] Huang Bo (Cortex Phellodendri Chinensis),[53] Huang Qin (Radix Scutellariae),[54] Lian Qiao (Fructus Forsythiae),[55] Long Dan (Radix et Rhizoma Gentianae),[56] Tian Hua Fen (Radix Trichosanthis),[57],[58] and Zhi Mu (Rhizoma Anemarrhenae).[59] Herbs with an antifungal effect include Huang Lian (Rhizoma Coptidis),[60] Huang Qin (Radix Scutellariae),[61] Niu Bang Zi (Fructus Arctii),[62] Zhi Zi (Fructus Gardeniae),[63] and Zhi Mu (Rhizoma Anemarrhenae).[64]

        Lastly, in today’s industrialized world, many cases of skin disorders are directly associated with exposure to certain allergens, chemicals, and toxins. Therefore, Gan Cao (Radix et Rhizoma Glycyrrhizae) and Fang Feng (Radix Saposhnikoviae) are used as they have antitoxin and antidotal effects to treat skin disorders caused by exposure to certain toxins and chemicals. Glycyrrhizin, generally considered to be one of the main constituents of Gan Cao (Radix et Rhizoma Glycyrrhizae), has a marked detoxifying effect to treat poisoning, including but not limited to drug poisoning (chloral hydrate, urethane, cocaine, picrotoxin, caffeine, pilocarpine, nicotine, barbiturates, mercury, and lead), food poisoning (tetrodotoxin, snake, and mushrooms), and others (enterotoxin, herbicides, and pesticides).[65] Furthermore, the use of Gan Cao (Radix et Rhizoma Glycyrrhizae), Fang Feng (Radix Saposhnikoviae), and Lu Dou (Semen Phaseoli Radiati) has been shown to be an effective antidote for arsenic poisoning.[66]

        In summary, Dermatrol (Damp) is a great formula to treat various skin disorders with damp/wet appearance. It has many herbs with a general dermatological effect to promote the growth and healing of human normal epidermal keratinocytes and dermal fibroblasts cell growths. It contains herbs with antiallergic and antipruritic effects to treat symptoms of itching and irritation. It utilizes herbs with anti-inflammatory effects to reduce swelling and inflammation. It incorporates herbs with antibiotic effects to treat skin infections. Finally, it incorporates herbs with antitoxin and antidote activities to treat skin disorders caused by exposure to certain toxins and chemicals.

 

COMPARATIVE ANALYSIS

Though there are many skin disorders with different causes and clinical manifestations, most skin disorders are treated with antibiotics, antihistamines, and anti-inflammatory drugs. Antibiotic substances (antibacterial, antiviral, and antifungal) are effective treatment options for skin infection caused by bacteria, virus and/or fungus. Antibiotics can be ingested orally or applied topically. Since skin disorders are often accompanied by itching, antihistamines are often used to block allergic reactions and to relieve itching through their sedative effects. For more severe cases of skin inflammatory disorders, topical or oral corticosteroids are used to reduce swelling and inflammation. In addition to these three main categories of drugs, moisturizing agents or drying agents are prescribed to treat dry and wet skin conditions, respectively. Moisturizing agents, such as creams or lotions with oil, put a thin film of oil on the skin and help the skin hold on to its natural moisture. Drying agents, such as talcum powder or aluminum salts, help to dry up excessive moisture and minimize infections in areas such as toes, buttocks, armpits and/or groins.

        In TCM, successful treatment of skin disorders requires the use of herbs to treat wind-heat at the exterior and toxic heat in the interior. Herbs that dispel wind-heat from the exterior generally have antihistamine and antipruritic effects, and are great to treat symptoms of itching and irritation. Herbs that clear toxic heat from the interior generally have an antibiotic effect to treat the infection and an anti-inflammatory function to reduce swelling and inflammation. Overall, herbs are a safe and effective option to treat skin disorders without the harsh side effects and adverse reactions of drugs.

        Drugs and herbs are both effective to treat skin disorders, and each has its inherent advantages and disadvantages. For skin disorders characterized by acute, severe or isolated incidence, such as exposure to poison oak, insect bite, and severe allergic or anaphylactic reactions, drugs are more effective as they are more potent and have a faster onset of action. Furthermore, such conditions are often treated aggressively but only for a short period of time, and therefore, side effects and adverse reactions of drugs can be managed and are not likely to create long-term problems. In contrast, skin disorders characterized by chronic and persistent nature, such as chronic idiopathic dermatitis or urticaria, will respond favorably to herbs. Finally, though drugs and herbs are both effective to symptomatically treat skin disorders characterized by allergic reactions, the only cure is to identify the allergen(s) and avoid any exposure to it if at all possible.

 



[1] Chan K, Lo AC, Yeung JH, Woo KS. Journal of Pharmacy and Pharmacology 1995 May;47(5):402-6.

[2] Pharmacotherapy 1999 July;19(7):870-876.

[3] European Journal of Drug Metabolism and Pharmacokinetics 1995; 20(1):55-60.

[4] Chen CY, Cheng KC, Chang AY, Lin YT, Hseu YC, Wang HM. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer. Int J Mol Sci. 2012;13(2):1762-77.

[5] Zhong Cao Yao Xue (Study of Chinese Herbal Medicine), 1980; 932.

[6] Zhong Yi Za Zhi (Journal of Chinese Medicine), 12:18.

[7] Han C, Guo J. Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens. Inflammation. 2011 Oct 6.

[8] Tian Jing Yi Xue Za Zhi (Journal of Tianjing Medicine and Herbology), 1966; 3:209.

[9] Kim DS, Son EJ, Kim M, Heo YM, Nam JB, Ro JY, Woo SS. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Unigen Inc., Cheonan, 330-863 Chungnam, Korea. Planta Med. 2010 May;76(7):678-82.

[10] Jung HS, Kim MH, Gwak NG, Im YS, Lee KY, Sohn Y, Choi H, Yang WM. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro. J Ethnopharmacol. 2012 May 7;141(1):345-9.

[11] Han EH, Park JH, Kim JY, Chung YC, Jeong HG. Inhibitory mechanism of saponins derived from roots of Platycodon grandiflorum on anaphylactic reaction and IgE-mediated allergic response in mast cells. BK21 Project Team, Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju, South Korea. Food Chem Toxicol. 2009 Feb 4.

[12] Kim H, Lee E, Lee S, Shin T, Kim Y, Kim J. Effect of Rehmannia glutinosa on immediate type allergic reaction. Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea. Int J Immunopharmacol. 1998 Apr-May;20(4-5):231-40.

[13] Sung YY, Yoon T, Jang JY, Park SJ, Kim HK. Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice. Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea. J Ethnopharmacol. 2011 Mar 8;134(1):37-44.

[14] Knipping K, van Esch EC, Wijering SC, van der Heide S, Dubois AE, Garssen J. In vitro and in vivo antiallergic effects of Arctium lappa L. University of Utrecht, Department of Pharmaceutical Sciences, Sorbonnelaan 16, 3508 TC Utrecht, The Netherlands. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77.

[15] Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim SY. Antiallergic and anti-inflammatory effects of butanol extract from Arctium Lappa L. Department of Pediatrics, College of Medicine, Hanyang University, Seoul, 133-792, Korea. Clin Mol Allergy. 2011 Feb 8;9(1):4.

[16] Lee B, Trinh HT, Jung K, Han SJ, Kim DH. Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus. Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, South Korea. Immunopharmacol Immunotoxicol. 2010 Sep;32(3):357-63.

[17] Tohda C, Kakihara Y, Komatsu K, Kuraishi Y. Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response. Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan. Biol Pharm Bull. 2000 May;23(5):599-601.

[18] Cuéllar MJ, Giner RM, Recio MC, Máñez S, Ríos JL. Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avda. Vicent Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain. Fitoterapia. 2001 Mar;72(3):221-9.

[19] Prieto JM, Recio MC, Giner RM, Máñez S, Giner-Larza EM, Ríos JL. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol. 2003 Sep;55(9):1275-82.

[20] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 888.

[21] Zhong Yao Zhi (Chinese Herbology Journal), 1993; 358.

[22] Zhong Cao Yao (Chinese Herbal Medicine), 1991; 22(10):452.

[23] Chao WW, Kuo YH, Li WC, Lin BF. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, National Taiwan University, Taipei 106, Taiwan, ROC. J Ethnopharmacol. 2009 Feb 25;122(1):68-75.

[24] Baek GH, et al. Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products. Inflammation. 2012 Feb 14.

[25] Ge WH, Guo JY, Shen YJ, Chen ML, Shi SL, Han YH, Lin J. Effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root on proinflammatory cytokine expression and regulation. Zhongguo Zhong Yao Za Zhi. 2007 Sep;32(17):1777-9.

[26] Wang CC, Chen LG, Yang LL. Inducible nitric oxide synthase inhibitor of the Chinese herb I. Saposhnikovia divaricata (Turcz.) Schischk. Cancer Lett. 1999 Oct 18;145(1-2):151-7.

[27] Chan BC, Hon KL, Leung PC, Sam SW, Fung KP, Lee MY, Lau HY. Traditional Chinese medicine for atopic eczema: PentaHerbs formula suppresses inflammatory mediators release from mast cells. J Ethnopharmacol. 2008 Oct 30;120(1):85-91.

[28] Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. School of Pharmacy, Yantai University, Yantai, Shandong, China. J Ethnopharmacol. 2009 Apr 21;122(3):457-62.

[29] Yang MH, Yoon KD, Chin YW, Park JH, Kim J. Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, South Korea. Bioorg Med Chem. 2009 Apr 1;17(7):2689-94.

[30] Chang Yong Zhong Yao Cheng Fen Yu Yao Li Shou Ce (A Handbook of the Composition and Pharmacology of Common Chinese Drugs), 1994, 368:376.

[31] Kim JY, Shin JS, Ryu JH, Kim SY, Cho YW, Choi JH, Lee KT. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University, Dongdaemun-Ku, Hoegi-Dong, Seoul 130-701, South Korea. Food Chem Toxicol. 2009 Jul;47(7):1610-7.

[32] Hwang SM, Lee YJ, Yoon JJ, Lee SM, Kang DG, Lee HS. Gardenia jasminoides inhibits tumor necrosis factor-alpha-induced vascular inflammation in endothelial cells. Professional Graduate School of Oriental Medicine, Wonkwang University, Chonbuk, Republic of Korea. Phytother Res. 2010 Jun;24 Suppl 2:S214-9.

[33] Chen ML, Xian YF, Ip SP, Tsai SH, Yang JY, Che CT. Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis. School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Planta Med. 2010 Oct;76(14):1530-5.

[34] Yu HH, Kim KJ, Cha JD, Kim HK, Lee YE, Choi NY, You YO. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. Department of Food and Nutrition, Kunsan National University, Kunsan. J Med Food. 2005 Winter;8(4):454-61.

[35] Zhang S, Zhang B, Xing K, Zhang X, Tian X, Dai W. Inhibitory effects of golden thread (Coptis chinensis) and berberine on Microcystis aeruginosa. Fisheries College, Ocean University of China, Qingdao 266003, P. R. China. Water Sci Technol. 2010;61(3):763-9.

[36] Zhong Yao Xue (Chinese Herbology), 1988; 137:140.

[37] J Pharm Pharmacol 2000 Mar;52(3):361-6.

[38] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983:149.

[39] Proc Natl Acad Sci, 1991; 88(15):6570.

[40] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 744.

[41] Shan Xi Xin Yi Yao (New Medicine and Herbology of Shanxi), 1980; 9(11):51.

[42] Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications of Chinese Herbs), 1983; 295.

[43] Zhong Yao Cai (Study of Chinese Herbal Material), 1991; 14(2):41.

[44] Zhong Yao Zhi (Chinese Herbology Journal), 1984; 578.

[45] Yao Xue Qing Bao Tong Xun (Journal of Herbal Information), 1987; 5(4):62.

[46] Zhong Hua Xin Yi Xue Bao (Chinese Journal of New Medicine), 1950; 1(5):95.

[47] Zhong Yao Xue (Chinese Herbology), 1988, 140:144.

[48] Zhong Hua Yi Xue Za Zhi (Chinese Journal of Medicine), 1958; 44(9):888.

[49] Zhong Xi Yi Jie He Za Zhi (Journal of Integrated Chinese and Western Medicine), 1989; 9(8):494.

[50] Zhong Yao Xue (Chinese Herbology), 1998; 103:106.

[51] Chiang LC, Chiang W, Chang MY, Lin CC. In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica. Am J Chin Med. 2003;31(2):225-34.

[52] Zhong Yao Tong Bao (Journal of Chinese Herbology), 1988; 13(6):364.

[53] Zhong Yao Xue (Chinese Herbology), 1998; 144:146.

[54] Błach-Olszewska Z, Jatczak B, Rak A, Lorenc M, Gulanowski B, Drobna A, Lamer-Zarawska E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland. J Interferon Cytokine Res. 2008 Sep;28(9):571-81.

[55] Shan Xi Xin Yi Yao (New Medicine and Herbology of Shanxi), 1980; 9(11):51.

[56] Li X, Zhou JY, Yang QW, Chen Y, Piao YA, Li HY. Inhibition activities of polysaccharide (RG4-1) from Gentiana rigescens against RSV. J Asian Nat Prod Res. 2011 Jun;13(6):512-22.

[57] Zheng YT, Ben KL, Jin SW. Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein. Acta Pharmacol Sin. 2000 Feb;21(2):179-82.

[58] Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y, Guo XK, Liu JX. In vitro anti-coxsackievirus B(3) effect of ethyl acetate extract of Tian-hua-fen. Department of Microbiology and Parasitology, Shanghai Second Medical University, Shanghai 200025, China. World J Gastroenterol. 2004 Aug 1;10(15):2263-6.

[59] Bae G, Yu JR, Lee J, Chang J, Seo EK. Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV). The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. Chem Biodivers. 2007 Sep;4(9):2231-5.

[60] Yu H.H., Kim K.J., Cha J.D., Kim H.K., Lee Y.E., Choi N.Y. & You Y.O. Antimicrobial Activity of Berberine Alone and in Combination with Ampicillin or Oxacillin Against Methicillin-Resistant Staphylococcus aureus . J Med Food. 2005, 8(4): 454-461.

[61] Wong KS, Tsang WK. In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans. Int J Antimicrob Agents. 2009 Sep;34(3):284-5.

[62] Zhong Yao Zhi (Chinese Herbology Journal), 1984; 250.

[63] Lelono RA, Tachibana S, Itoh K. Isolation of antifungal compounds from Gardenia jasminoides. United Graduate School of Agricultural Sciences, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan. Pak J Biol Sci. 2009 Jul 1;12(13):949-56.

[64] Iida Y, Oh KB, Saito M, Matsuoka H, Kurata H, Natsume M, Abe H. Detection of antifungal activity in Anemarrhena asphodeloides by sensitive BCT method and isolation of its active compound. Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan. J Agric Food Chem. 1999 Feb;47(2):584-7.

[65] Zhong Yao Tong Bao (Journal of Chinese Herbology), 1986; 11(10):55.

[66] Xin Yi Xue (New Medicine), 1973; 7:6.