Liver DTX ™
* Liver detoxification: enhances the normal metabolic and detoxification functions of the liver
* Liver damage with elevated liver enzymes
* Hepatitis with or without jaundice
* Liver cirrhosis caused by alcohol, drugs or other chemicals
* Addiction treatment: detoxifies liver from alcohol, drugs, and other chemicals
WESTERN THERAPEUTIC ACTIONS
* Enhances the liver function by increasing the regeneration of liver cells
* Protects the liver from damage caused by alcohol, drugs or other chemicals
* Treats liver cirrhosis by preventing and repairing liver damage
* Antioxidant effects to neutralize free radicals and prevent cell damage
* Lowers elevated levels of hepatic enzymes
CHINESE THERAPEUTIC ACTIONS
* Clears heat and eliminates toxins
* Spreads the Liver qi
* Drains dampness
* Tonifies deficiency
Take 3 to 4 capsules three times daily on an empty stomach with warm water.
Bai Shao (Radix Paeoniae Alba)
Chai Hu (Radix Bupleuri)
Da Huang (Radix et Rhizoma Rhei)
Fu Ling (Poria)
Ge Hua (Flos Puerariae)
Hu Zhang (Rhizoma et Radix Polygoni Cuspidati)
Huang Qin (Radix Scutellariae)
Ma Bian Cao (Herba Verbenae)
Pu Tao Zi (Semen Vitis Vinifera)
Qing Pi (Pericarpium Citri Reticulatae Viride)
Shui Fei Ji (Fructus Silybi)
Wu Wei Zi (Fructus Schisandrae Chinensis)
Yin Chen (Herba Artemisiae Scopariae)
Yu Jin (Radix Curcumae)
Zhi Zi (Fructus Gardeniae)
The liver is an organ responsible for many metabolic functions: formation and excretion of bile, carbohydrate homeostasis, lipid synthesis, cholesterol metabolism, and metabolism or detoxification of drugs and other foreign substances. Liver disorders are often caused by infections, drugs, toxins, ischemia and autoimmune diseases. Liver disorders are characterized by abnormal laboratory test results (i.e., elevated ALT and AST) and symptoms (i.e., jaundice, right upper quadrant pain). Treatment varies depending on the exact disease and its cause.
According to traditional Chinese medicine, liver disorders are characterized by damp-heat or toxic heat in the Liver. Liver DTX is formulated to eliminate damp-heat, clear toxic heat, and regulate Liver qi. Clinical applications include hepatitis, liver cirrhosis, and cholecystitis. It can also be used to protect the liver and lower liver enzymes secondary to the use of drugs and alcohol, and subsequent to viral infections.
To detoxify the liver, the treatment protocol is to strengthen the liver function. Capillarisin, one of the active ingredients of Yin Chen (Herba Artemisiae Scopariae), increases the secretion of bile, bile salts and bilirubin. It increases the regeneration of liver cells and is an indispensable herb when treating jaundice or cholecystitis. Chai Hu (Radix Bupleuri) is a channel-guiding herb and is also extremely effective in protecting the liver cells from denaturalization and necrosis. It is often used to decrease liver enzymes in patients with fatty liver or chronic hepatitis. Ge Hua (Flos Puerariae) relieves alcohol poisoning. Hu Zhang (Rhizoma et Radix Polygoni Cuspidati), Zhi Zi (Fructus Gardeniae), Huang Qin (Radix Scutellariae) and Da Huang (Radix et Rhizoma Rhei) clear heat, eliminate toxins and improve the liver function. Bai Shao (Radix Paeoniae Alba) nourishes the Liver blood. Ma Bian Cao (Herba Verbenae) enters the Liver channel to clear heat and detoxify. Fu Ling (Poria) strengthens the Spleen and promotes the excretion of toxins through urination. Yu Jin (Radix Curcumae) benefits the Gallbladder and the Liver in treating viral hepatitis. It also invigorates blood circulation to promote generation of new liver cells. Qing Pi (Pericarpium Citri Reticulatae Viride) spreads the stagnant Liver qi and relieves constraint. Wu Wei Zi (Fructus Schisandrae Chinensis) improves the Liver function in patients with hepatitis. Both Pu Tao Zi (Semen Vitis Vinifera) and Shui Fei Ji (Fructus Silybi) have excellent hepatoprotective and antioxidant functions.
In summary, Liver DTX eliminates damp-heat and clears toxic heat to enhance liver function and treat liver disorders.
CAUTIONS & CONTRAINDICATIONS
* Liver DTX is contraindicated during pregnancy and nursing. It should be used with caution in cases of qi and yang deficiencies.
* Do not use this formula to treat acute liver failure – such conditions must be sent to the emergency room for immediate medical care.
* Decrease the dosage to two capsules twice a day if there is loose stool after taking the herbs.
* The following warning statement is required by the State of California: “This product contains Da Huang (Radix et Rhizoma Rhei). Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Da Huang (Radix et Rhizoma Rhei) may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.”
* Laboratory tests are extremely useful in diagnosis, treatment, and prognosis assessment for patients with liver dysfunction. Understanding the implications of laboratory tests empowers healthcare practitioners to effectively treat hepatic and gallbladder disorders.
* Elevation of liver enzymes is common in hepatitis. Though Western medicine has treatments for lowering liver enzymes, the results are often unsatisfactory, especially in chronic hepatitis B. Therefore, herbs that clear heat, remove dampness, strengthen the Spleen and regulate the Liver are used to normalize liver enzyme levels. In addition, small dosages of blood-activating and stasis-removing herbs can be used together for their synergistic effect. Patients should continue to take herbs for a period of time after liver enzyme levels return to normal to prevent a rebound increase of liver enzymes.
* Liver cirrhosis is a common complication of chronic hepatitis infection. To reduce the risk of developing cirrhosis of the liver in chronic hepatitis, use large dosages of Dan Shen (Radix et Rhizoma Salviae Miltiorrhizae) with regular dosages of Hong Hua (Flos Carthami). Addition of Bie Jia (Carapax Trionycis) to the herbal formula will further reduce the risk of developing liver cirrhosis.
* The five main reasons hepatitis B patients remain chronic carriers of the hepatitis B virus:
1. Enhanced or suppressed immunity. Patients with irregular immune systems are less likely to become negative on the HBV exam. Indications of irregular immune system include high or low levels of IgG, IgM and IgA.
2. Frequent infection of the oral region indicates a suppressed immunity. This can be treated with Ye Ju Hua (Flos Chrysanthemi Indici) and Gan Cao (Radix et Rhizoma Glycyrrhizae).
3. Seasonal factors. The treatment of hepatitis is less effective in spring and summer. In spring, there is a higher incidence of Liver qi damaging the yin. In summer, the damp-heat in the environment may increase dampness and heat inside the body. Thus, the ideal seasons to treat hepatitis B are autumn and winter. To enhance the overall effectiveness of the treatment, Yi Guan Jian (Linking Decoction) can be added in autumn and Liu Yi San (Six-to-One Powder) can be added in summer.
4. Increase in liver enzymes such as AST and ALT.
5. Dietary restrictions. Patients should reduce their intake of alcohol, hot and spicy food, and any other foods that worsen the condition.
Pulse Diagnosis by Dr. Jimmy Wei-Yen Chang:
* Wiry, forceful, and deep pulse on the left guan
* For cholecystitis or gallstones with elevated liver enzymes, combine with Dissolve (GS).
* For fatty liver, add Cholisma (ES).
* With jaundice, add Yin Chen Hao Tang (Artemisia Scoparia Decoction).
* For excess fire signs and symptoms throughout the body, add Gardenia Complex.
* For dark complexion and blood stagnation, add Circulation (SJ).
* To enhance the antibacterial function, add Herbal ABX.
* To enhance the antiviral function, add Herbal AVR.
* To reduce inflammation, add Astringent Complex.
* For stomach discomfort, heartburn, and/or acid reflux, add GI Care.
* With IBS or bloating, add GI Harmony.
* To detox the colon, add GI DTX.
* For heavy metal, chemical or environmental poisoning, add Herbal DTX.
* For compromised kidney function, use Kidney DTX.
* To enhance the immune system, add Immune +.
* For a quick burst of energy and awareness, combine with Vibrant.
* To tonify the underlying deficiencies of qi, blood, yin and yang, use Imperial Tonic.
* Taichong (LR 3), Xingjian (LR 2), Ganshu (BL 18), Zusanli (ST 36)
* Xingjian (LR 2), Taichong (LR 3), Fenglong (ST 40), Sanyinjiao (SP 6), Ganshu (BL 18), Danshu (BL 19)
Classic Master Tung’s Points:
* Hepatitis (acute): Ganmen (T 33.11), Changmen (T 33.10), Xinmen (T 33.12), Linggu (T 22.05), Muyan (T 11.20), Ganlingsan (T 33.18)*, Tianhuang (T 88.13), Qihuang (T 88.14), Minghuang (T 88.12), Shuitong (T 1010.19), Tongguan (T 88.01), Shuijin (T 1010.20), Menjin (T 66.05), Muhuang (T 88.47)*, Muling (T 11.29)*. Needle every other day. Bleed Huobao (T 55.01) or nearby dark veins. Bleed before needling for best result.
* Hepatitis (toxins/medication): Fenzhishang (T DT.01), Fenzhixia (T DT.02), Ganmen (T 33.11), Minghuang (T 88.12), Huoquan (T 88.16), Qihuang (T 88.14). Needle every day.
* Liver cirrhosis: Ganlingsan (T 33.18)*, Minghuang (T 88.12), Qihuang (T 88.14), Tianhuang (T 88.13), Muyan (T 11.20), Yizhong (T 77.05), Erzhong (T 77.06), Sanzhong (T 77.07), Ganmen (T 33.11), Huozhi (T 88.15), Renhuang (T 77.21), Tianhuangfu [Shenguan] (T 77.18). Needle everyday until condition stabilizes. Bleed Shangqu (T 44.16) or nearby dark veins. Bleed before needling for best result.
Master Tung’s Points by Dr. Chuan-Min Wang:
* Hepatitis: Changmen (T 33.10), Ganmen (T 33.11)
* Jaundice: Qihuang (T 88.14), Huozhi (T 88.15), Huoquan (T 88.16)
* Cirrhosis: Needle Ganmen (T 33.11), Minghuang (T 88.12), Tianhuang (T 88.13), Qihuang (T 88.14). Bleed Quchi (LI 11).
* Elevated liver enzymes, addiction, toxin in the Liver: Minghuang (T 88.12), Tianhuang (T 88.13), Qihuang (T 88.14), Ganmen (T 33.11), Fenjin (T 44.01)
Balance Method by Dr. Richard Tan:
* Left side: Hegu (LI 4), Zhizheng (SI 7), Ligou (LR 5), Ququan (LR 8). Ganmen,Liver and Pancreas on the ear.
* Right side: Neiguan (PC 6), Ximen (PC 4) or ah shi points nearby, Yanglingquan (GB 34), Zusanli (ST 36) or ah shi points nearby. Liver and Pancreas on the ear.
* Left and right sides can be alternated from treatment to treatment.
* To detoxify the liver: use three needles on the Liver or embed needles on the Liver point.
Auricular Medicine by Dr. Li-Chun Huang:
* Hepatitis: Liver, Gall Bladder, Rib Rim, Spleen, San Jiao, Endocrine, Abdominal Distension Area, Digestive Subcortex, Ear Center, Hepatitis
* Patients with liver cirrhosis should increase the intake of vitamin K found in such foods as green leafy vegetables, almonds, bananas, kelp, prunes, raisins, rice, wheat bran, and seeds. They should increase their intake of vegetables, especially artichokes, carrots, and beets. Water intake should be increased.
* Artichokes contain cynarin, a substance that stimulates the bile flow and regulates the liver.
* Patients with hepatitis should avoid alcohol, sugar, fat, raw fish, shellfish and highly-processed foods with chemicals or food additives. Fat, butter, margarine, cheese, fish, fowl, meat, salt, soft drinks, sugar, tea, cod liver oil, vitamin A, and spicy and fried foods should be eliminated from the diet. Also avoid over-eating, cigarette smoking, alcohol, coffee, and drugs.
* Patients with jaundice should not consume alcohol, raw or undercooked fish, meat or poultry.
The Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:
* Liver cleansing
§ Drink beet top tea, or combine with dandelion herb and make tea.
§ To help liver detoxify, juice collard greens with kale, mustard greens, carrots, celery, and cucumber. Drink 1 to 2 glasses daily.
* Liver toxicity
§ Make vegetable juice from chard, kale, spinach, beet and carrot greens, carrot, apple and one tablespoonful of spirulina or chlorella. Consume one to two glasses daily.
§ Recommendations: rice, barley, millet, azuki beans, pearl barley, squash, cucumber, grapefruit, dandelion greens, beet greens, pears, water chestnut, carrot, cabbage, spinach, celery, winter melon, rice vinegar, pineapple, and lotus root.
§ Cook lotus root and puree, then cook into rice or millet porridge.
§ Juice watermelon, celery and pears.
§ Make mung bean soup with pearl barley.
§ Soak grapefruit and peel in rice vinegar overnight, then take one teaspoon in one cup of warm liquid.
§ Take cucumber juice on empty stomach every morning.
§ Avoid dairy products, alcohol, coffee, sugar, fatty and fried foods, overly spicy foods, cold and raw foods, tomato, eggplant, bell peppers, and shellfish.
* Avoid physical and mental stress and exhaustion whenever possible. Maintain a cheerful and positive outlook and avoid dramatic emotional swings.
* Avoid exposure to toxins whenever possible, including but not limited to chemicals, heavy metals, herbicides, pesticides, and environmental pollutants.
* Physical stimulation to the back by scratching or intense massage will stimulate the liver to increase activity.
* D.T., a 56-year-old male patient, presented with elevated liver enzymes and high cholesterol. The practitioner diagnosed the condition as Liver blood and yin deficiencies with blood stasis and Spleen deficiency. He was treated with Liver DTX at 4 capsules three times daily for one month, followed by Cholisma at 4 capsules three times daily for two months, gradually reducing thereafter. As a result of the treatment, his blood work revealed normal liver enzymes after one month of taking Liver DTX along with cholesterol levels within normal range after two months of taking Cholisma. After one year his cholesterol levels remained great and he continued to take a maintenance dose of Cholisma. Submitted by A.G., Solana Beach, California.
* D.D., a 45-year old business owner, who was a single mom and had less than four hours of sleep each night, presented with chronic eczema and itchy skin. Objective findings were red and heavy eyes and the location of her rash was mainly on her hands and feet. She had recently lost over 50 pounds and was still trying to lose more weight. The practitioner diagnosed this condition as damp-heat and Liver disharmony. Dermatrol (PS) was prescribed at three pills three times daily along with Liver DTX at the same dosage. The results were positive; she experienced less itching and her rashes were less. However, during times of stress and lack of sleep the rash and itching symptoms would return. The patient’s compliance with her lifestyle was needed for prolonged results. Submitted by L.W., Arroyo Grande, California.
* J.K., a 35-year-old male, presented with alcoholism, with a constant urge to drink. However, he did not want to do AA. Other than this, the patient was otherwise considered to be healthy. The patient had also just previously quit smoking cold turkey. For treatment the patient was given Calm (ES) and Liver DTX in conjunction with receiving acupuncture. As a result, the patient reported that he no longer had the urge to drink and was also being less reactive. The practitioner had also counseled the patient that this was not a stand alone treatment for alcoholism and advised the patient to go seek more help. Submitted by B.L., Fort Myers, Florida.
* W.G., a 23-year-old male, presented with toxicity due to recreational drugs. The TCM diagnosis was toxic heat in the Liver as well as throughout the entire body. For treatment, Liver DTX and Herbal DTX were prescribed. The patient noticed a significant detoxification in response to taking both formulas. In comparison, he had noticed the Liver DTX working more through the urine and the Herbal DTX working throughout the entire body. He was very in-tune with his body and testified that these formulas were very helpful to his condition. Submitted by B.S., Niceville, Florida.
* A 57-year-old female presented with an enlarged liver. There was a history of hepatitis and she had a cholecystectomy. Symptoms included shortness of breath, edema in the upper body, and liver enzyme elevation. The TCM diagnosis was Spleen qi deficiency with phlegm engendering the organs. Liver DTX and Cholisma (ES) were both prescribed for five months. Her liver was normal in size without any discrete mass. As a result of taking the herbs, the patient’s overall condition had improved. It was confirmed through additional testing of her liver that it was back to normal. She hasn’t had any issues since. Submitted by H.C., Sydney, New York.
* A 41-year-old male complained of occasional bouts of irritability. He had elevated liver enzymes, elevated HCT and was positive for Hepatitis C. The practitioner diagnosed his condition as damp-heat in the Liver and Gallbladder. After taking Liver DTX, the liver enzyme levels tested within normal limits. The patient’s medical doctor, after recognizing all supporting evidence, encouraged the herbal treatment wholeheartedly. Submitted by P.C., Stanwood, Washington.
* M.C., a 49-year-old highly-stressed executive, presented elevated SGPT, LDL and cholesterol levels. He stated he frequently checked his blood pressure and it ranged from 135-148/85-91 mmHg. He was never diagnosed with hypertension but had an upcoming insurance physical and wanted to lower his blood pressure naturally [without using drugs]. He also complained of low-grade temporal headaches, pressured feeling in the head, and neck and shoulder tension. His blood pressure at the time of examination was 148/94 mmHg and his heart rate was 72 beats per minute. He worried excessively, in part because his son was diagnosed with brain tumor ten years ago. He also suffered from insomnia, and fist clenching that lasted throughout the day. He said that his stress caused numbness and tension on his left shoulder and rhomboid area. The TCM diagnoses were Liver qi stagnation and Spleen qi deficiency. Cholisma at 4 capsules three times daily and Liver DTX at 5 capsules at night were prescribed. He reported after taking the herbs, he passed his exam for insurance. Blood pressure has stayed down at 120/72 mmHg. His stress was manageable and there were no more headaches. Energy level was also excellent. His cholesterol levels had also dropped from 216 to 186 mg/dL. The practitioner reported that the patient is now a believer of herbs. Submitted by M.H., West Palm Beach, Florida.
* A 45-year-old female with insulin-dependent diabetes presented with malaise, fatigue, night sweats, hot flashes and low back pain. She also had abdominal bloating, red eyes, weak nails and a pale complexion. She was diagnosed with hepatitis C. The practitioner prescribed Liver DTX (3 capsules three times daily) and Equilibrium (3 capsules three times daily). Also given was a pancreatic homeopathic remedy (10 drops 6 times a day) and another homeopathic remedy, Hepan Comp (1 drop three times daily). Two and a half months later, the patient discontinued her insulin use. Her viral load was almost within the normal range and she decided to discontinue all pharmaceuticals. There was a total reversal of her clinical picture. Submitted by I.B., Miami, Florida.
* A 68-year-old retired male complained of diminishing vision. In turn, he became frustrated with the fact that he was no longer able to play tennis as well as before or competitively. Other visual dysfunctions included a reduction in visual field and the inability to track objects. The practitioner diagnosed the patient’s condition as Liver qi stagnation and Liver fire with underlying Liver yin deficiency. The practitioner suspected blood leakage into the post-retinal layer, which would have been indicative of a detached retina. The patient was given Liver DTX. Along with the herbal treatment, the practitioner also stressed the importance of diet, especially devoid of alcohol and sugar. Although the patient was not completely compliant with the treatment, his visual compromise stabilized and the deterioration stopped. The practitioner observed a reversal of the patient’s symptoms and anticipated an encouraging prognosis. Submitted by T.W., Santa Monica, California.
* J.J., a 45-year-old male, presented with tiredness, aching joints, occasional jaundice, bleeding gums and nose, thirst, foul and sticky bowel movements, short-temper, irritability, disturbed sleep, dry eyes and floaters. His tongue was red, quivering and the tip was red. His pulse was wiry on both sides. Blood pressure was 125/80 mmHg and the heart rate was 72 beats per minute. Western medical diagnosis was Hepatitis C. The TCM diagnosis was damp-heat in the Liver, Liver blood deficiency and Liver overacting on the Spleen. Liver DTX combined with Huang Bo (Cortex Phellodendri Chinensis) was prescribed totaling 12 grams a day. Omega-3 fatty acids were also recommended at 1 tablespoon per day. Patient had a very recent liver profile done before the treatment. Within three weeks of acupuncture and herbal treatments, his total liver profile (by a new blood test) imbalances were reduced by over 66%. He felt amazingly better. No bloating or hypochondrial pain. Digestion was much improved, as well as energy and well-being. Proper dietary recommendations were also implemented. The practitioner reported that he consistently found the Liver DTX to be an amazing and very powerful formula, especially with hepatitis. Submitted by M.N., Knoxville, Tennessee.
* A 44-year-old female with hepatitis C, necrosis of the liver, and diabetes (insulin-dependent) was treated with interferon, Rebetron (ribavirin and interferon α 2B), Zantac (ranitidine), Prozac (fluoxetine) and insulin. Her clinical manifestations included pain in the liver region, fatigue, insomnia, blurred vision, constipation, melancholy, frontal headache, dizziness, tremors, abdominal bloating, and a pale complexion. Her tongue was maroon in color, and the pulse was slippery. The diagnosis for this patient was dampness in the Liver and Gallbladder, with Liver overacting on the Spleen and the Stomach, hence disrupting the transformation and transportation of the digestive system. The patient was treated with two herbal formulas (Liver DTX and Imperial Tonic) and two homeopathic formulas (sarcode liver formula and oral insulin). The treatment also included acupuncture involving meridian treatment and extraordinary vessel treatment. After three weeks, the patient had significant improvements in her vitality, complexion, appetite, sleep, attitude and energy level. A dramatic reduction of her abdominal pain was also noted. Her insulin use was reduced by approximately 25%. Submitted by I.B., Miami, Florida.
* A 22-year-old female presented with high triglycerides and high ALT. The patient appeared thin and pale. Her limbs were always cold and she was easily agitated. Her blood pressure was 115/70 mmHg and the heart rate was 72 beats per minute. The TCM diagnosis was yang deficiency with heat in the Liver. Liver DTX at 3 capsules three times a day was prescribed with Cholisma at 2 capsules twice a day. She also received acupuncture. After six weeks, her liver enzymes and triglycerides levels returned to normal. Submitted by W.F., Bloomfield, New Jersey.
* M.C., a 49-year-old male, presented with elevated SGPT levels (72, normal 0-40) but his medical doctor told him it was normal. At age 8, this patient suffered from a blood disorder called “Fatty Bone Marrow” with no hemoglobins. He was treated but the results were reported to be moderate in effectiveness. There was negative history for any liver disorders. His blood pressure was 120/72 mmHg and his heart rate was 62 beats per minute. The TCM diagnoses were Spleen qi deficiency and Liver qi stagnation. He was instructed to take 5 capsules of Liver DTX at bedtime for three months. After the herbs, the SGOT level reduced to 21 and the SGPT level to 32. The patient was thrilled. Submitted by M.H., West Palm Beach, Florida .
* A 36-year-old female patient presented with severe hangover from excessive alcohol consumption. Clinical signs and symptoms included nausea, vomiting, anorexia, frontal headache, diarrhea, and extreme weakness and fatigue. Her tongue was pale and flabby, with a moist, greasy tongue coating. Her face was pale and puffy, with dark, sunken eyes. The Western diagnosis was acute alcohol intoxication; the TCM diagnosis was damp-heat in the Liver and Gallbladder, with qi deficiency. Liver DTX was prescribed at four capsules every four to six hours for one day. Within two hours after taking the first dose, the patient reported that she felt 98% improvement, and said that she had regained her strength and appetite. She stated that her headache, nausea, vomiting and diarrhea had all diminished. She took the second dose, ate a large meal, and recovered from alcohol intoxication. Submitted by C.L., Chino Hills, California.
* M.F., a 57-year-old female, presented with pain in the leg and big toe with pressure, metallic taste, absence of thirst, heat sensations except in the hands and feet, and upper body sweating. She had been exposed to toxic chemicals and pesticides for six months. The TCM diagnosis was yin deficiency with heat, damp-heat and toxic heat accumulation, and bi zheng (painful obstruction syndrome) of the legs. After six weeks of taking Liver DTX, Balance (Heat) and Flex (NP), she experienced less leg pain, decreased sweating, subsiding heat sensations, and warmer hands. The patient still had a metallic taste in the mouth. The patient also increased her intake of carrot juice and cucumbers. Submitted by M.C., Sarasota, Florida.
PHARMACOLOGICAL AND CLINICAL RESEARCH
Liver DTX is formulated with herbs that enhance the normal metabolic rate and detoxification functions of the liver. Herbs in Liver DTX have demonstrated functions to increase the regeneration of liver cells, protect the liver from damage by foreign chemicals and substances,1 prevent and repair liver damage, and lower elevated levels of liver enzymes.
Shui Fei Ji (Fructus Silybi), also known as milk thistle, is one of the main ingredients in Liver DTX. The use of Shui Fei Ji (Fructus Silybi) can be traced back over 2,000 years to a Greek reference when Pliny the Elder (A.D. 23-79) first noted it had an excellent effect to “carry off bile.” Today, Shui Fei Ji (Fructus Silybi) is well documented for having both hepatoprotective and nephroprotective effects against Tylenol (acetaminophen)-induced liver and kidney toxicities. The mechanism of action is attributed to its antiapoptotic, antioxidant and anti-inflammatory activities. Silymarin, one active compound from Shui Fei Ji (Fructus Silybi), has been found to have hepatoprotective and antioxidant effects. Silymarin protects the liver by changing the outer liver cell membrane and preventing the entrance of toxins into the liver cells.5, Specific indications for silymarin include cirrhosis and hepatitis. Silymarin was found to be effective in treating alcoholic cirrhosis as concluded by a 41-month double-blind study of 170 patients.4 Silymarin also improved liver function in 20 patients with chronic active hepatitis.
Wu Wei Zi (Fructus Schisandrae Chinensis) has a marked hepatoprotective effect and is frequently used to treat various liver disorders. Studies have shown that administration of Wu Wei Zi (Fructus Schisandrae Chinensis) is associated with a marked hepatoprotective effect against various types of drugs and/or chemical-induced toxicities. In one study, a preparation of Wu Wei Zi (Fructus Schisandrae Chinensis) significantly lowered liver enzymes in subjects with elevated SGPT levels caused by intraperitoneal injection of 0.1% carbon tetrachloride. The mechanisms of hepatoprotective function of Wu Wei Zi (Fructus Schisandrae Chinensis) are attributed to the alteration of liver cell membrane permeability to prevent the entry of toxic substances, and increased blood flow to the liver and increased regeneration of liver cells.,Clinically, Wu Wei Zi (Fructus Schisandrae Chinensis) is frequently used to treat hepatitis and lower liver enzymes. In one study, oral ingestion of Wu Wei Zi (Fructus Schisandrae Chinensis) (3 to 6 grams in powdered herb mixed with honey) three times daily for one month per course of treatment effectively lowered liver enzyme levels to normal. Another study reported an 85.3% rate of effectiveness using 3g of powdered Wu Wei Zi (Fructus Schisandrae Chinensis) three times daily to treat 102 cases of non-icteric infectious hepatitis. Furthermore, one study reported that oral ingestion of Wu Wei Zi (Fructus Schisandrae Chinensis) in honey pills effectively lowered liver enzymes in 67 of 80 patients with chronic hepatitis. Lastly, an herbal formula with Wu Wei Zi (Fructus Schisandrae Chinensis) was used with a 97% rate of effectiveness (33 out of 34 patients) in the treatment of chronic hepatitis.
Yin Chen (Herba Artemisiae Scopariae), Da Huang (Radix et Rhizoma Rhei) and Zhi Zi (Fructus Gardeniae), three herbs used in Yin Chen Hao Tang (Artemisia Scoparia Decoction), are important herbs with significant activities to treat liver and gallbladder disorders. Pharmacologically, these three herbs have been shown in many studies to effectively protect the liver from various drug- or chemical-induced hepatitis, including Tylenol (acetaminophen), carbon tetrachloride, α-naphthylisothiocyanate (ANIT), and concanavalin A.,, The mechanism of this action is attributed to inhibited production of inflammatory cytokines and enhanced production of anti-inflammatory cytokines. According to the research, administration of these three herbs may be useful for treating severe acute hepatitis accompanying cholestasis in cases of autoimmune hepatitis. Clinically, these three herbs have been used successfully to treat acute infectious icteric hepatitis, acute icteric hepatitis, acute viral hepatitis, jaundice, and biliary atresia.
Liver DTX contains many other herbs to directly and indirectly protect the liver and treat liver disorders. Chai Hu (Radix Bupleuri) has hepatoprotective activity that protects the liver against carbon tetrachloride-induced liver damages and inhibits the growth of liver cancer cells.,Bai Shao (Radix Paeoniae Alba) illustrates marked antiviral activity against hepatitis B virus (HBV) to inhibit the HBV multiplication and decrease the level of extracellular HBV. Daidzin and daidzein, two compounds from Ge Gen (Radix Puerariae Lobatae) and Ge Hua (Flos Puerariae), have marked antialcoholic effects and help to treat liver damage associated with consumption of large amounts of ethanol. Hu Zhang (Rhizoma et Radix Polygoni Cuspidati) contains resveratrol, which has demonstrated a hepatoprotective effect by lowering the liver enzymes SGOT and SGPT. Clinical studies have shown Hu Zhang (Rhizoma et Radix Polygoni Cuspidati) to effectively treat chronic hepatitis with positive HbsAg. Huang Qin (Radix Scutellariae) has a remarkable effect to protect and prevent various types of liver injuries. Huang Qin (Radix Scutellariae) protects against mutagenesis of liver cells induced by the mycotoxin aflatoxin-B1. It also protects against fibrosis and lipid peroxidation in the liver induced by bile duct ligation and scission or by carbon tetrachloride. In one clinical study, 268 patients with infectious or chronic hepatitis were treated with Huang Qin (Radix Scutellariae) through oral administration and intramuscular injection. The duration of treatment was one month for both oral therapy (0.5 grams of baicalin three times daily) and injection therapy (60 to 120 mg of baicalin via intramuscular or intravenous injection). The effective rate was 63.6% for patients with infectious hepatitis and 73.3% for chronic hepatitis.
In summary, Liver DTX is an excellent formula with numerous mechanisms of hepatoprotective effect to prevent and treat various liver disorders.
Liver diseases, such as hepatitis and liver cirrhosis, are serious and very complicated diseases. In Western medicine, these conditions are usually treated with interferon. These drugs, however, have limited success, but are extremely expensive and create significant number of serious side effects, including dizziness, confusion, coma, arrhythmia, heart failure, leukopenia, thrombocytopenia, and many others. In severe and life threatening cases, such as liver cirrhosis and liver cancer, surgery may be performed.
In traditional Chinese medicine, treatment of liver disorders is also a very challenging and complicated matter. These conditions are usually treated with herbs that drain damp-heat from the Liver. Pharmacologically, these herbs have hepatoprotective effects that remove toxins from the liver, prevent the entrance of toxins into the liver cells, and increase blood circulation to the liver to facilitate recovery. In most cases, herbs are most effective in the early stages of liver disorder characterized by increased liver enzymes. Immediate and aggressive treatment with herbs generally lowers liver enzyme levels and reverses the illness. Once the disease progresses into various stages of hepatitis and/or liver cirrhosis, customized herbal treatments should be considered for maximum effectiveness.
Liver diseases, such as hepatitis and liver cirrhosis, are serious and very complicated diseases that are challenging to both Western and traditional Chinese medicine. Herbal treatment is generally more effective for the early stages of liver disease, and ones with mild to moderate severity. Drug treatment, such as with interferon, are generally not utilized unless there is moderate to severe liver disease, because the risk of side effects are generally greater than the potential benefits. Unfortunately, severe cases of liver diseases are extremely difficult to manage for both Western medicine and traditional Chinese medicine. Under these circumstances, customized treatment with careful supervision is most effective.
 Olin, B. et al. The Lawrence Reviews of Natural Products by Facts and Comparisons. Milk Thistle, January 1997.
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