C/R Support ™
CLINICAL
APPLICATIONS
* Chemotherapy/radiation support: side effects and adverse reactions associated with these treatments * Myasthenia gravis * Chronic fatigue syndrome * Prolapse of organs such as the stomach, rectum, uterus and bladder * Anorexia and wasting syndrome WESTERN
THERAPEUTIC ACTIONS
* Chemoprotective and radioprotective benefits to prevent, minimize, or reverse adverse reactions associated with chemotherapy or radiation * Immunostimulant effect to increase both specific and non-specific immunity * Hematopoietic function to increase the production of red blood cells CHINESE
THERAPEUTIC ACTIONS
* Tonifies the Spleen and the Stomach * Tonifies yin and moistens dryness * Tonifies the wei (defensive) qi * Harmonizes the middle jiao DOSAGE
Take 3 to 4 capsules three times daily as a maintenance dose. Dosage may be increased to 5 to 6 capsules three times daily for cancer patients receiving chemotherapy, or radiation treatments. C/R Support should be taken on an empty stomach with warm water for maximum effectiveness. Honey can also be added to enhance the taste of the herbs, tonify qi and harmonize the middle jiao. INGREDIENTS
Bai Zhu (Rhizoma
Atractylodis Macrocephalae) Chen Pi
(Pericarpium Citri Reticulatae) Dang Gui
(Radix Angelicae Sinensis) Di Huang (Radix
Rehmanniae) Dong Chong Xia Cao
(Cordyceps) Gou Qi Zi (Fructus Lycii) Huang Qi (Radix Astragali) Ling Zhi (Ganoderma) Mai Dong (Radix Ophiopogonis) Ren Shen (Radix et Rhizoma Ginseng) Shi Di (Calyx Kaki) Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata
cum Melle) Zhu Ru (Caulis
Bambusae in Taenia) BACKGROUND
Cancer is the second leading cause of death, according
to a report by the CDC published in January 11, 2012.[1] In Western
medicine, treatment options for cancer include surgery, chemotherapy, and
radiation. Though these treatments may be effective, they are invasive to the
body and often cause severe and serious damages to many organs and cells.
Therefore, additional interventions are extremely important to alleviate the
side effects of these invasive treatments, support the body and its health, and
improve the overall quality of life. FORMULA
EXPLANATION
C/R Support is an herbal formula specifically designed to support patients with cancer as they undergo chemotherapy and radiation treatments. Though effective against cancer cells, chemotherapy and radiation destroy normal tissue and healthy cells and cause a wide array of side effects and adverse reactions, including but not limited to nausea, vomiting, hair loss, weakness and fatigue. For cancer patients receiving chemotherapy and radiation, C/R Support complements the overall treatment by enhancing the immune system, reducing the side effects of the drug treatment, inhibiting the growth of cancer cells, and boosting the energy and vitality of the patient. Huang Qi (Radix Astragali) is the chief herb in this formula. It replenishes the vital qi, consolidates the wei (defensive) qi, and protects against external pathogenic factors. It has anticancer effects to increase the content of cAMP and inhibit the growth of tumor cells. Ling Zhi (Ganoderma) tonifies blood and vital energy, increases the white blood cell count, and inhibits the growth of various viruses and bacteria. Dong Chong Xia Cao (Cordyceps) is essential in rebuilding the patient¡¦s constitution and is used for chronically debilitated patients. Shi Di (Calyx Kaki), Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae Praeparata cum Melle) and Zhu Ru (Caulis Bambusae in Taenia) tonify the Spleen and Stomach of the middle jiao to prevent nausea, vomiting and stomach discomfort. Chen Pi (Pericarpium Citri Reticulatae) strengthens the Spleen and dispels phlegm. Di Huang (Radix Rehmanniae), Gou Qi Zi (Fructus Lycii), and Mai Dong (Radix Ophiopogonis) treat thirst and dryness by replenishing body fluids. Dang Gui (Radix Angelicae Sinensis) augments the yin and blood and relieves thirst and dryness. Ren Shen (Radix et Rhizoma Ginseng) and Bai Zhu (Rhizoma Atractylodis Macrocephalae) tonify the Spleen qi to increase both energy and appetite during radiation treatments. C/R Support can also be used to treat prolapse of internal organs, such as the stomach, rectum, bladder, or uterus. Huang Qi (Radix Astragali), Ling Zhi (Ganoderma), Ren Shen (Radix et Rhizoma Ginseng), and Bai Zhu (Rhizoma Atractylodis Macrocephalae) tonify qi, ascend yang, and raise the prolapse of internal organs. Similarly, qi and yang tonic herbs in this formula help to relieve chronic fatigue syndrome, anorexia, wasting syndrome, and myasthenia gravis. CAUTIONS
& CONTRAINDICATIONS * C/R Support is not designed to treat cancer or replace chemotherapy and radiation. Its main focus is to complement chemotherapy and radiation treatments by strengthening the overall constitution of the patient and minimize the side effects. * This formula is contraindicated
in cases of excessive heat, damp heat, infection or inflammation. * This herbal formula contains herbs that invigorate blood circulation, such as Dang Gui (Radix Angelicae Sinensis). Therefore, patients who are on anticoagulant or antiplatelet therapies, such as Coumadin (warfarin), should use this formula with caution, or not at all, as there may be a higher risk of bleeding and bruising.[2],[3],[4] * The
safety status of using Dang Gui
(Radix Angelicae Sinensis) in individuals with hormone-dependent cancer is
unclear.[5],[6],[7]
According to
one reference, use of Dang Gui (Radix
Angelicae Sinensis) is not associated with
thickening of the
endometrium or vaginal cell maturation, both of which would indicate an
estrogenic effect. Furthermore, there is no confirmation of the presence of a phytoestrogen
component or effect on hormone-dependent cancer when ferulic acid is evaluated
as the main component of Dang Gui (Radix Angelicae Sinensis).[8]
According to another reference, the water extract of Dang Gui (Radix Angelicae Sinensis) has a weak estrogen-agonistic
activity to stimulate the growth of breast cancer cells (MCF-7).[9] In
summary, due to conflicting and insufficient data, use of Dang Gui (Radix Angelicae Sinensis) in patients with
hormone-dependent cancer warrants caution pending further study. CLINICAL
NOTES
* C/R Support has a wide range of clinical applications. Its use is not limited to cancer patients receiving chemotherapy and radiation. * C/R Support contains herbs with immune-enhancing, anticancer activities, and energy-boosting properties. It will benefit cancer patients, whether or not they are receiving chemotherapy and radiation treatments. Pulse
Diagnosis by Dr. Jimmy Wei-Yen Chang:
* Overall weakness, including weak immune system: tent pulse, a convex-shaped pulse that collapses upon pressure * Weak digestion: small pulse, a weak and thin pulse that disappears upon pressure, on the right guan SUPPLEMENTARY
FORMULAS
* For patients with cancer who have extreme weakness and deficiency and cannot tolerate chemotherapy or radiation treatment, use CA Support. * To enhance
the immune system during or after chemotherapy or radiation treatment,
add Immune +. * For cancer of
the lung and reproductive systems, add Cordyceps 3 to strengthen the constitution of these two organs. * For hair loss
during chemotherapy or radiation treatment, combine with Polygonum 14 to nourish qi and blood and prevent hair damage. * For maintenance at the conclusion of chemotherapy or radiation treatment, take Cordyceps 3, Imperial Tonic and Immune + on a long-term basis. * For poor appetite
and loose stools from Spleen deficiency caused by chemotherapy or radiation,
add GI Tonic. * For Kidney yin
deficiency, add Kidney Tonic (Yin). * For Kidney yang
deficiency, add Kidney Tonic (Yang). * For constipation,
add Gentle Lax (Deficient). * For pain due to
cancer, add Herbal ANG. * For stress and
anxiety, use Calm. * For
stress, anxiety, and insomnia, use Calm ZZZ. * For
a quick boost of energy and vitality, use Vibrant. ACUPUNCTURE
TREATMENT Traditional
Points:
*
Zusanli (ST 36),
Fuliu (KI 7), Neiguan (PC 6),
Pishu (BL 20), Weishu (BL 21), Hegu (LI 4), Shanzhong (CV 17) Classic
Master Tung's Points:
*
Bladder
cancer/tumor: Simazhong (T 88.17),
Tongshen (T 88.09), Wanshunyi
(T 22.08), Tianhuangfu [Shenguan] (T 77.18), Shuangling (T 11.28)*, Waisanguan (T 77.27), Zhiwu (T 11.26) *
Bone cancer/tumor: Bilateral Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Minghuang (T 88.12), Tianhuang
(T 88.13), Qihuang (T 88.14), Shuangling (T 11.28)*, Tianhuangfu [Shenguan] (T 77.18), Zhiwu (T 11.26). Needle everyday. Bleed HT and LU area below the knee. The more the
blood is let out, the better the result. * Brain cancer/tumor: Shangliu (T 55.06), Zhengjin (T 77.01), Zhengzong
(T 77.02) with strong stimulation, Yizhong
(T 77.05), Erzhong (T 77.06), Sanzhong (T 77.07), Shuangling (T 11.28)*, Zhiwu
(T 11.26). Bleed dark veins nearby the medial malleolus or Shuijing (T 66.13). Bleed before needling for best result. *
Breast
cancer/tumor: Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Yizhong (T 77.05), Erzhong
(T 77.06), Sanzhong (T 77.07), Shuanglongyi (T 77.29)*, Shuanglonger (T 77.30)*, Zhiwu (T 11.26). Bleed all dark
veins nearby the HT, LU area on the legs [maximum of 150 mL for each time of
bleeding). Bleed before needling for best result. *
Chondroma: Simashang (T 88.18), Simazhong (T 88.17), Dihuang (T 77.19), Renhuang (T 77.21,
Tianhuangfu [Shenguan] (T 77.18), Fuyuan (T 11.22), Shuangling (T
11.28), Zhiwu (T 11.26). Bleed the
affected area. Bleed before needling for best result. * Colon cancer/tumor: Sanzhong (T
77.07), Zuwujin (T 77.25), Zuqianjin (T 77.24), Tianhuang (T 88.13), Minghuang (T 88.12), Cesanli (T 77.22), Simazhong (T 88.17), Shuangling
(T 11.28)*, Zhiwu (T 11.26). Bleed Sihuashang (T 77.08), Sihuazhong (T 77.09), Sihuaxia (T 77.11), Fuchang (T 77.12), or dark veins nearby. Bleed the LU
area below the knee. Bleed before needling for best result. The more the blood
is let out, the better the effect. * Fallopian tube
cancer/tumor: Fuke (T
11.24), Huanchao (T 11.06), Sanzhong (T 77.07), Jiemeiyi (T 88.04), Jiemeier
(T 88.05), Jiemeisan (T 88.06), Shuangling (T 11.28)*, Zhiwu (T 11.26). Bleed dark veins
nearby Daling (PC 7), Yinxi
(HT 6). Bleed before needling for best result. The more the blood is let out,
the better the effect. * Gallbladder
cancer/tumor: Minghuang (T
88.12), Qihuang (T 88.14), Huozhi (T 88.15), Shuangling (T 11.28)*, Zhiwu
(T 11.26) * Kidney cancer/tumor: Tianhuang (T 77.17), Dihuang (T 77.19), Renhuang (T 77.21), Tongshen
(T 88.09), Wanshunyi (T 22.08),
Shuangling (T 11.28)*, Zhiwu (T 11.26) * Liver cancer/tumor: Minghuang (T 88.12), Tianhuang (T 88.13), Qihuang (T 88.14), Huoying (T 66.03), Tianhuangfu
[Shenguan] (T 77.18), Shuangling
(T 11.28)*, Zhiwu (T 11.26). Needle
everyday. * Lung cancer/tumor: Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Linggu (T 22.05), Dabai (T 22.04), Shuangling (T
11.28)*, Waisanguan (T 77.27), Xinchang (T 11.19), Zhiwu (T
11.26). Bleed
the LU area below the knee. Bleed before needling for best result. The more the
blood is let out, the better the effect. * Lymphatic
cancer/tumor: Wanshunyi (T 22.08), Yizhong
(T 77.05), Erzhong (T 77.06), Sanzhong (T 77.07), Cesanli (T 77.22), Tianhuangfu
[Shenguan] (T 77.18), Huoying (T
66.03), Shuangling (T 11.28)*, Zhiwu (T 11.26). Bleed the LU area below the knee. The more the blood is let out,
the better the effect. * Nasal cancer/tumor: Linggu (T 22.05), Dabai
(T 22.04), Simashang (T 88.18), Simazhong
(T 88.17), Simaxia (T 88.19), Fugesan (T 44.30)*, Shuangling (T 11.28)*, Zhiwu
(T 11.26). Bleed
the LU area below the knee. Bleed before needling for best result. The more the
blood is let out, the better the effect. * Oral
cancer/tumor: Bleed Shaoshang
(LU 11), Sihuazhong (T 77.09), mouth
area, Zhiwu (T 11.26). Bleed before
needling for best result. The more the blood is let out, the better the effect. * Osteosarcoma: Piyi (T 88.35)*, Pier
(T 88.36)*, Simazhong (T 88.17), Tianhuangfu [Shenguan] (T 77.18), Huoying (T 66.03), Fuyuan (T 11.22), Shuangling (T 11.28)*, Zhiwu
(T 11.26). Bleed
around affected area. The more the blood is let out, the better the result. * Ovarian, uterus, cervix cancer/tumor: Fuke (T 11.24), Huanchao (T 11.06), Zhiwu (T 11.26), Shuangling (T 11.28)*, Qimen
(T 33.01), Qijiao (T 33.02), Qizheng (T 33.03), Yunbai (T 44.11), Menjin
(T 66.05), Waisanguan (T 77.27), Tianhuang (T 77.17), Dihuang (T 77.19), Renhuang (T 77.21), Jiemeiyi
(T 88.04), Jiemeier (T 88.05), Jiemeisan (T 88.06), Mufu (T 88.38)*, Tongshen (T 88.09), Tongbei
(T 88.11). Bleed the dark veins nearby the web between the first and
second toes; and second and third toes. Bleed sacral area with cupping.
Bleed before needling for best result. The more the blood is let out, the
better the effect. * Pancreatic
cancer/tumor: Piyi (T
88.35)*, Pier (T 88.36)*, Pisan (T 88.37)*, Yizhong (T 77.05), Erzhong
(T 77.06), Sanzhong (T 77.07), Minghuang (T 88.12), Qihuang (T 88.14), Shuangling (T 11.28)*, Zhiwu
(T 11.26) * Stomach cancer/tumor: Cesanli (T 77.22), Waisanguan (T 77.27), Shuangling
(T 11.28)*, Zhiwu (T 11.26). Bleed
dark veins nearby the ST area in the lower limb. Bleed before needling for best
result. The more the blood is let out, the better the effect. * Testicular cancer/tumor: Dajian (T 11.01), Xiaojian (T 11.02), Waijian (T 11.04), Fujian (T 11.03), Shuangling
(T 11.28)*, Zhiwu (T 11.26) * Throat cancer/tumor:
Tongguan (T 88.01), Cesanli (T 77.22), Yizhong (T 77.05), Erzhong
(T 77.06), Sanzhong (T 77.07), Linggu (T 22.05), Dabai (T 22.04),
Sihuashang (T 77.08), Zuqianjin (T 77.24), Zuwujin (T 77.25), Waisanguan (T 77.27), Shuangling
(T 11.28)*, Zhiwu (T 11.26). Bleed dark veins
nearby Shaoshang
(LU 11), nine points evenly on the neck, or the back of the neck or the ST
channel on the lower limb. Bleed before needling for best result. The more the
blood is let out, the better the effect. * Thyroid
cancer/tumor: Xinling (T
33.17)*, Simashang (T 88.18), Simazhong (T 88.17), Simaxia (T 88.19), Waisanguan (T 77.27), Shuangling
(T 11.28)*, Zhiwu (T 11.26). Bleed Sihuazhong (T 77.09) and back of the
neck. Bleed before needling for best result. The more the blood is let out, the
better the effect. * Tongue
cancer/tumor: Cesanli (T
77.22), Houjian (T 44.29)*, Minghuang (T 88.12), Qihuang (T 88.14), Shuangling (T 11.28)*, Zhiwu
(T 11.26). Bleed
the LU area below the knee. Bleed before needling for best result. The more the
blood is let out, the better the effect. * Vaginal
cancer/tumor: Fuke (T
11.24), Huanchao (T 11.06), Libai (T 44.12), Yunbai (T 44.11), Sanzhong
(T 77.07), Shuangling (T 11.28)*, Zhiwu (T 11.26). Bleed dark veins
nearby Daling (PC 7), Yinxi
(HT 6). Bleed before needling for best result. The more the blood is let out,
the better the effect. Master
Tung¡¦s Points by Dr. Chuan-Min Wang:
* Chemotherapy, radiation, myasthenia gravis, organ
prolapse, anorexia, wasting: Zhenghui (T 1010.01), Zhengben
(T 1010.12), Zhongbai (T 22.06) Balance
Method by Dr. Richard Tan:
*
Digestive
symptoms due to chemotherapy or radiation: ¡± Left side: Neiguan (PC 6), Lieque (LU 7), Zusanli (ST 36), Yanglingquan (GB 34) ¡± Right side: Zhigou (TH 6), Hegu (LI 4), Yinlingquan (SP 9), Ququan (LR 8) ¡± Left and right sides can be alternated from
treatment to treatment. Ear
Acupuncture:
*
Pain due to cancer ¡± Main points: Subcortex, Heart, correlating
diseased organ ¡± Adjunct points: Sympathetic, Liver, Shenmen *
Select
four to six points each time.
Alternate the ear treatments every two days. Auricular
Medicine by Dr. Li-Chun Huang:
*
Nausea:
Cardia, Stomach, Liver, Shenmen,
Occiput, Digestive Subcortex *
Fatigue:
Sympathetic, Kidney, Liver, Spleen, San
Jiao, Anxious, Nervous Subcortex, Speed Recovered Fatigue. Bleed Ear Apex. *
Edema at
arm pit after breast cancer surgery: San
Jiao, Arm Pit, Spleen, Endocrine, Large Auricular Nerve. Bleed Helix 4. * Promoting immunity: Allergic Area, Endocrine, Adrenal Gland, Spleen, Liver. Bleed Ear Apex and Helix 1-6. NUTRITION
* Eat a variety of fresh, organic
fruits and vegetables of all colors. *
Incorporate more high fiber whole
grains and nuts into the diet. *
Drink warm or hot liquids with
meals. Putting cold and ice on any part of the body will immediately constrict
the flow of blood to that region. Similarly, drinking cold or iced drinks with
meals will hinder the natural peristaltic movements of the digestive system. * Foods with antioxidant effects, such as vitamin A, C and E are beneficial as they neutralize the free radicals and minimize damage to cells. Beneficial foods include citrus fruits, carrots, green leafy vegetables, and green tea. *
Chew food completely and
thoroughly. The digestive tract can process and absorb smaller pieces of food
much better than food that is incompletely chewed. Larger pieces of food can
lead to incomplete digestion and digestive discomfort. *
Always eat breakfast. According
to the TCM clock, the most optimal time for the digestive system is in the
morning from 8 to 10 a.m. *
Give the body two to three hours
between the last meal of the day and bedtime. During sleep, the digestive
system slows down as well. Make sure the body has adequate time to digest the
food before going into sleep mode. * If the patient is allergic to any
food or feels uncomfortable after eating certain foods, avoid eating them. * Avoid fast food, processed foods, junk food, artificial sugars, and carbonated drinks. Stay away from meat, greasy food, alcohol, caffeine, dairy products (except for unsweetened low-fat yogurt), tap water, iron supplements and vegetables and fruits with pesticides. * For patients who have breast cancer, the following foods are especially beneficial: all mushrooms, whole grains, broccoli, brussel sprouts, cabbage, cauliflower, yellow/orange vegetables (carrots, pumpkins, squash, sweet potatoes), fresh garlic, onions, fresh berries, apples, cherries, grapes, and plums. * Ginger can always be used to relieve nausea. Boil ten slices of ginger for five minutes and mix with brown sugar. Slices of fresh ginger can also be chewed or sucked on for a stronger and immediate effect. *
The Spleen is responsible for generating post-natal
qi and good Spleen function also contributes to a healthy immune system. Foods
that damage the Spleen should be avoided: ¡± Avoid any and all foods that
contain sugar, such as cake, dessert, candy, chocolate, canned juice, soft
drinks, caffeinated drinks, stevia, sugar substitutes, agave, xylitol, and corn
syrup. ¡± Avoid raw or uncooked meats, such
as sashimi, sushi, steak tartar, and seared meat. Minimize consumption of foods
that are cooling in nature, including tofu, tomato, celery, asparagus, bamboo,
seaweed, kelp, bitter melon, cucumber, gourd, luffa, eggplant, winter melon,
watermelon, honeydew, citrus, oranges, guava, grapefruit, pineapple, plums, pear,
banana, papaya, white radish, mustard leaf, potherb mustard, Chinese kale,
napa, bamboo sprout. Do not eat foods straight from the refrigerator. Long-term
intake of cold fruits and vegetables like the ones listed above may be damaging
to the Spleen. The cooling property of foods can be neutralized by cooking or
adding 20 pieces of Gou Qi Zi
(Fructus Lycii). ¡± Avoid carbohydrates like white
rice or bread as they may produce dampness. ¡± No seafood especially shellfish,
like crabs, oyster, scallops, clams, lobster and shrimp (they enter the yangming
Stomach channel). ¡± Avoid fermented foods like cheese
or fermented tofu. ¡± Do not eat dairy products, such
as milk, cream, yogurt, cheese, and ice cream. ¡± No lamb, beef, goose or duck. ¡± Avoid fried or greasy foods. * Warm and hot foods that damage qi and yin should be avoided, such as: ¡± Avoid certain fruits like mango
and durian that produce heat. ¡± Avoid spicy foods and stimulants
like coffee, alcohol, and energy drinks. ¡± Avoid spicy/pungent/aromatic
vegetables such as pepper, garlic, onions, basil, rosemary, cumin, funnel,
anise, leeks, chives, scallions, thyme, saffron, wormwood, mustard, chili
pepper, and wasabi. * Avoid food and drinks with
artificial coloring. * Consume as few meat products as
possible. Do not eat processed meats, such as lunch meats, hot dogs and
sausages, as they contain nitrites that are associated with inflammation and
chronic disease. The
Tao of Nutrition by Dr. Maoshing Ni and Cathy McNease:
* Blend shitake or ganoderma
mushrooms and white fungus, boil and drink the soup three times a day. * Boil together mung beans,
pearl barley, azuki beans, and figs. This makes a delicious dessert that will
aid appetite and sustain energy levels. * Avoid meat, chicken, coffee,
cinnamon, anise, pepper, dairy products, spicy foods (except garlic), high fat
foods, cooked oils, chemical additives, moldy foods, smoking, constipation,
stress, and all irritations. LIFESTYLE
INSTRUCTIONS
* Avoid radiation from microwaves and limit prolonged exposure to appliances with high electromagnetic output, such as television, computer monitors, electric stoves, cellular phones, and other popular electronic devices. * Relax, exercise regularly (tai chi chuan * tai ji quan], qi gong or yoga). Maintain a positive outlook on life. * Avoid the consumption of alcohol and exposure to tobacco or nicotine in any form. * Avoid stress and anxiety whenever possible. They suppress the immune system, slow down the metabolic process, and foster the development of cancer. * Avoid wearing tight bras, which can cut off lymphatic flow, obstruct elimination of toxins and increase risk of tumor growth. * Sleep by 10:00 p.m. In TCM, 11:00 p.m. to 1:00 a.m. is when the yin shifts to yang. It is crucial for the body to be at rest during this time for optimal health. CASE
STUDIES
*
E.F., a 47-year-old female with uterine cancer,
has been receiving chemotherapy for the previous ten months. She was
experiencing numbness of her mouth and jaw, and losing her sense of taste and
smell as a result of the chemotherapy. The practitioner diagnosed the condition
as Kidney and Spleen qi deficiencies. She was instructed to take C/R Support. At first, she was only taking the herbs sporadically, but once
she noticed the pain went away when taking them, she took them regularly. Her
Western doctor commented that the patient¡¦s appetite had increased, compliments
to the herbs, which was very important when undergoing her chemotherapy.
Submitted by C.W., Santa
Barbara, California. * In July 1999, a 66-year-old
retired business woman was brought in for acupuncture and herbal treatments.
She was seriously ill from severe chronic anorexia triggered by intolerance to
chemotherapeutic treatment following radiation and surgery for cancer of the
vocal cords. Approximately 5¡¦4¡¨ tall, the woman was curled up in the fetal
position, weighing 85 lbs., cold, lethargic, nauseous and exceedingly anxious.
She had had one previous occurrence of the cancer two years before, and felt
she was in danger of dying, if not from the cancer, then from the treatment.
She began taking small doses of C/R Support granules stirred into
warm water, as she could not swallow anything but liquids. She continued with C/R Support for several weeks, later augmented with Bu
Zhong Yi Qi Tang (Tonify the Middle and Augment the
Qi Decoction),
but found it difficult to incorporate a second herbal formula, so she relied on
C/R Support for approximately eight months. No further
chemotherapeutic or radiation treatment was attempted, at the direction of her
M.D. oncologist and at the patient¡¦s wishes. Within three weeks of beginning
treatment, the woman was able to resume eating small meals of well-cooked foods,
and within two months, she was gaining weight noticeably and regaining color in
her face. Her voice was a strained whisper initially, gradually regaining some
volume and tone. Because the underlying pathogens in her case were Lung heat,
Heart fire, and dryness with persistent phlegm, her herbal formula was
gradually changed to half C/R Support, and half additional
ingredients to address the heat, dryness and phlegm. At approximately 24 months
into treatment, C/R Support was discontinued, although the
patient continues to take herbs specific to her imbalance and seek acupuncture
weekly. Because of emotional issues related to her throat, compliance with her
herbal regime is difficult for the patient: she seldom takes the full dosage or
recommended frequency; however, she states she tries to become more and more
consistent. She has regained normal weight and vitality, returning to an active
¡¥retired¡¦ home and social life. As of January 2002, she continues to receive
¡¥cancer free¡¦ reports from her oncologist and surgeon, and is seeing gradual
improvement in her voice, thirst levels
and phlegm. Submitted by L.C., Santa Monica, California. * A 69-year-old male presented in July 1999 with advanced multiple myeloma, brittle bones, chronic intense pain in his back and hips, digestive difficulties, deficient constipation and hair loss. He is an entertainment professional and concerned about being able to preserve his career in the face of medical expenses and the emotional satisfaction of continuing to work. His blood cancer count was high and remained somewhat high through February 2001, when it was 2,100. He began taking C/R Support at the normal dosage in July 1999, combined over time with a normal dosage of either Nourish, Shou Wu Pian (Polygonum Pills), or You Gui Wan (Restore the Right [Kidney] Pill), depending on the symptoms presented at his weekly visits for acupuncture and herbal consultation. He continued on C/R Support through the middle of 2001, transitioning at that point to individualized formulas specific to his underlying digestive weakness, osteoporosis and pain. Although the osteoporotic aspects of his illness continue to make him vulnerable to skeletal injury and pain, he has maintained 80% of the hairline he had upon presenting for treatment, and has been able to continue working in his profession. His blood cancer counts in December 2001 were below 300. He states he continues to feel he is improving. Submitted by L.C., Santa Monica, California. * K.E., a 45-year-old female, presented with ovarian cancer and C/R Support was prescribed at 2 grams three times a day. She was instructed to take 4 grams three times daily if her white blood cell count was low. She also received acupuncture treatment in addition to the herbs. Patient reported that she felt okay during the chemotherapy and stayed relatively healthy and kept the white blood cell count healthy. Submitted by W.F., Bloomfield, New Jersey. PHARMACOLOGICAL
AND CLINICAL RESEARCH
C/R Support is formulated specifically to offer chemotherapy or radiation support for patients with cancer. Chemotherapy or radiation work by killing cancer cells that multiply rapidly. Unfortunately, as these treatments destroy fast-growing cancer cells, they can also cause serious damages to fast-growing healthy cells, such as red blood cells, white blood cells, bone marrow cells, hair follicles and cells in the digestive tract (mouth, throat, stomach and intestines). So while it may be important to use chemotherapy or radiation to treat cancer, it is equally important to use herbs to alleviate the side effects of these harsh treatments and improve the quality of life. C/R Support is formulated with many herbs specifically to alleviate the side effects of many chemotherapy drugs and radiation treatments. Dong Chong Xia Cao (Cordyceps) is effective to alleviate leukopenia caused by Taxol (paclitaxel) by protecting both hematopoietic progenitor cells directly and the bone marrow stem cell niche through its effects on osteoblast differentiation.[10] Gou Qi Zi (Fructus Lycii) shows a protective effect against Adriamycin (doxorubicin)-induced cardiotoxicity through antioxidant-mediated mechanisms.[11] Gou Qi Zi (Fructus Lycii) is also an excellent option to treat myelosuppression induced by chemotherapy or radiation.[12] Ling Zhi (Ganoderma) has shown many benefits to support patients treated with chemotherapy or radiation. It prevents nephrotoxicity caused by Platinol (cisplatin) by reversing the increase in urea, creatinine levels and ALP activity and also maintaining the renal antioxidant defense.[13] Ling Zhi (Ganoderma) also alleviates many Cytoxan (cyclophosphamide)-induced toxicities, such as decrease in body weight, natural killer activity, interferon-gamma production, and cytotoxic T lymphocyte activity.[14] Ren Shen (Radix et Rhizoma Ginseng) has a significant effect to protect the gastrointestinal tract of cancer patients who receive radiation treatment. It also protects the hematopoietic system and increases the number of bone marrow cells and spleen cells.[15] Lastly, Huang Qi (Radix Astragali) has been shown in multiple studies to alleviate side effects associated with chemotherapy. Huang Qi (Radix Astragali) significantly attenuated cardiotoxicity induced by Cerubidine (daunorubicin) by decreasing free radical release and apoptosis in cultured neonatal cardiomyocytes.[16] It is also effective to restore the depressed immune functions in subjects with tumor treated with Cytoxan (cyclophosphamide).[17] Finally, Huang Qi (Radix Astragali) promotes myelopoiesis and enhances hematopoiesis in subjects with myelosuppression caused by Cytoxan (cyclophosphamide).[18] C/R Support contains many herbs with general immunostimulant and immunomodulatory effects. Huang Qi (Radix Astragali) has been
shown repeatedly through modern research to increase both specific and
non-specific immunity.[19],[20],[21] Bai Zhu (Rhizoma Atractylodis
Macrocephalae) has been shown to increase the activity of the
macrophages and
reticuloendothelial system, and elevate the number of white blood cells,
lymphocytes, and IgG.[22],[23] Gou Qi Zi (Fructus Lycii) has an
effect to increase non-specific immunity and boost phagocytic activity of the macrophages and
the total number of T cells.[24] Ren Shen (Radix et Rhizoma Ginseng) has immune-enhancing effects to increase the function of the
reticuloendothelial system and increases the total count of IgM.[25] Dong Chong Xia Cao (Cordyceps) is another herb
that has demonstrated immunomodulatory functions. It enhances the overall immunity
by increasing the number of lymphocytes and natural killer cells, and the
production of interleukin, interferon and tumor-necrosis-factor.[26],[27],[28],[29],[30] Cordysinocan,
a polysaccharide isolated from cultured Dong Chong Xia Cao (Cordyceps), activates immune responses in cultured
T-lymphocytes and macrophages to signal the cascade and induction of cytokines.[31] Lastly,
Ling Zhi (Ganoderma) has a wide
range of therapeutic effects in the treatment of cancer. Various clinical
studies have demonstrated the effects of Ling Zhi
(Ganoderma) to enhance the immune system.[32],[33],[34],[35] The
specific effects of Ling
Zhi (Ganoderma)
include an increase in monocytes, macrophages, and T lymphocytes as well as an
increased production of cytokine, interleukin, tumor-necrosis-factor, and
interferon. Ling
Zhi (Ganoderma)
has also been used to successfully
treat leukopenia.[36] In addition, C/R Support also contains many herbs with hematopoietic effects to increase the production of red blood cells. Specifically, administration of Gou Qi Zi (Fructus Lycii) in decoction has been shown to increase the production of red blood cells and white blood cells.[37] Huang Qi (Radix Astragali) has been shown to increase the production and maturity of blood cells from the bone marrow.[38] Furthermore, use of Dang Gui (Radix Angelicae Sinensis) in Si Wu Tang (Four-Substance Decoction) showed a marked hematopoietic effect to increase red blood cells for the treatment of anemia. [39] The mechanism of action is attributed to increased activity of colony-stimulating factors (CSF).[40] In summary, C/R Support is an important formula for chemotherapy or radiation support. It contains herbs that alleviate the side effects of chemotherapy and radiation, and improves the quality of life for the patient. COMPARATIVE ANALYSIS Despite
all the advances in medicine, treatment of cancer is still in its relative
infancy in both Western and traditional Chinese medicine. Optimal
treatment methods may include chemotherapy, radiation and/or surgery. Though
they may be effective, they are extremely harsh and create a huge number of
side effects, including severe nausea, vomiting, hair loss, and most
importantly, bone marrow suppression with decreased counts of red and white
blood cells. Serious cases of bone marrow suppression often necessitate the
termination of chemotherapy and radiation treatments, a scenario where the
patient suffers from both cancer and its treatments at the same time. Use
of herbs is extremely effective to complement chemotherapy and radiation. Not
only do they alleviate many side effects of chemotherapy and radiation, they
strengthen the overall constitution of the body so they can tolerate and finish
the entire course of therapies. Optimal
therapy in cases of cancer is not to choose between Western or
traditional Chinese medicine, but to integrate Western and
traditional Chinese medicines together. These two modalities of medicine
complement each others, and provide the brightest outlook and prognosis for
successful treatment of cancer. [1] [2] Chan K, Lo AC, Yeung JH, Woo KS. Journal of Pharmacy
and Pharmacology 1995 May;47(5):402-6. [3] Pharmacotherapy 1999 July;19(7):870-876. [4] European Journal of Drug Metabolism and
Pharmacokinetics 1995; 20(1):55-60. [5] Natural Standard
(www.naturalstandard.com). [6] National Institutes of Health. [7] U.S National Library of Medicine. [8] American Herbal Pharmacopoeia. Dang Gui (Radix Angelicae Sinensis) monograph. [9] Lau CB, Ho TC, Chan TW, Kim
SC. Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal
symptoms in women with breast cancer: is it appropriate? Menopause 2005 Nov-Dec;12(6):734-40. [10] Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH,
Chiang CS. Cordyceps sinensis health supplement enhances recovery from
taxol-induced leukopenia. Exp Biol Med ( [11] Xin YF, Zhou GL, Deng ZY, Chen YX, Wu YG, Xu PS, Xuan
YX. Protective effect of Lycium barbarum on
doxorubicin-induced cardiotoxicity. Phytother
Res. 2007 Nov;21(11):1020-4. [12] Gong H, Shen P, Jin L, Xing C, Tang
F. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation
or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm. 2005
Apr;20(2):155-62. [13] Pillai TG, John M, Sara
Thomas G. Prevention of cisplatin induced nephrotoxicity by terpenes isolated
from Ganoderma lucidum occurring in Southern Parts of India. [14] Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso
Y, Abe S. Effects of the antlered form of Ganoderma lucidum on tumor growth and
metastasis in cyclophosphamide-treated mice. Institute for Health Care Science,
Suntory Ltd., Mishima-gun, [15] Park E, Hwang I, Song JY, Jee Y. Acidic polysaccharide of Panax ginseng as a defense
against small intestinal damage by whole-body gamma irradiation of mice.
Applied Radiological Science Research Institute, [16] Luo Z, Zhong L, Han X, Wang H, Zhong J, Xuan Z.
Astragalus membranaceus prevents daunorubicin-induced apoptosis of cultured
neonatal cardiomyocytes: role of free radical effect
of Astragalus membranaceus on daunorubicin cardiotoxicity. Shanghai Institute
of Hematology, [17] Cho WC, Leung KN. In vitro and in
vivo immunomodulating and immunorestorative effects
of Astragalus membranaceus. Department of Clinical
Oncology, [18] Zhu XL, Zhu BD. Mechanisms by which
Astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. Department of Pharmacology,
School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Haidian Qu, Beijing
100083, China. Phytother Res. 2007 Jul;21(7):663-7. [19] [20] Sun, Y. et al. Immune restoration and/or augmentation
of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer. July 1983; 52(1):70-3. [21] Sun, Y. et al. Preliminary
observations on the effects of the Chinese medicinal herbs astragalus
membranaceus and ganoderma lucidum on lymphocyte blastogenic responses. Journal of Biological Response Modifiers. 1983; 2(3):227-37. [22] Jun Shi Yi Xue Jian Xun (Military Medicine
Notes), 1977; 2:5. [23] Xin Yi [24] Zhong Cao [25] Zhong Yao Xue (Chinese Herbology), 1998; 729:736. [26] Kuo,YC.
et al. Cordyceps sinensis as an immuno-modulatory
agent. American Journal Of Chinese Medicine.
24(2):111-25, 1996 [27] Guan, YJ. et
al. Effect of cordyceps sinensis on T-lymphocyte subsets in chronic renal
failure. Chung-Kuo Chung His I Chieh Ho Tsa Chih. Jun. 1992; 12(6):338-9,323. [28] Liu, C. et al. Effects of cordyceps sinensis (CS) on
in vitro natural killer cells. Chung-Kuo Chung His I Chieh Ho Tsa Chih. May. 1992; 12(5):267-9,259. [29] Xu, RH. et al. Effects of
cordyceps sinensis on natural killer activity and colony formation of B16
melanoma. Chinese Medical Journal. Feb.
1992; 105(2):97-101. [30] Liu, P. et al. Influence of cordyceps sinensis (berk.)
sacc. and rat serum containing same medicine on IL-1,
IFN and TNF produced by rat Kupffer's cells. Chung Kuo Chung [31] Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CW,
Duan R, Choi RC, Lau DT, Dong TT, Lau BW, Tsim KW. Cordysinocan, a polysaccharide isolated from
cultured Cordyceps, activates immune responses in cultured T-lymphocytes and
macrophages: signaling cascade and induction of cytokines. J Ethnopharmacol. 2009 Jul 6;124(1):61-8.
[32] Wang, SY. et al. The
anti-tumor effect of ganoderma lucidum is mediated by cytokines released from activated
macrophages and t-lymphocytes. International Journal Of
Cancer. Mar 17. 1997; 70(6):699-705. [33] Van Der Hem, LG. et al. Ling Zhi-8: Studies of a new
immunomodulating agent. Transplantation. Sep
15. 1995; 60(5):438-43. [34] Haak-Frendscho, M. et al. Ling
Zhi-8: A novel t-cell mitogen induces cytokine production and up-regulation of
ICAM-1 expression. Cellular Immunology. Aug.
1993; 150(1):101-13. [35] Tanaka, S. et al. Complete amino
acid sequence of a novel immuno-modulatory protein, ling zhi-9. an immuno-modulator from a fungus, ganoderma lucidum, having
similar effect to immunoglobulin variable regions. [36] Zhong Hua Xue Yi Za Zhi (Chinese Journal of
Hematology), 1985; 7:428. [37] Zhong Yao Xue (Chinese Herbology), 1998; 860:862. [38] Nan Jing Zhong Yi Xue Yuan Xue
Bao (Journal of [39] Shan Xi
Zhong Yi Xue Yuan Xue Bao
(Journal of [40] Zhong Yao |